L
Lukáš Lacina
Researcher at First Faculty of Medicine, Charles University in Prague
Publications - 65
Citations - 1922
Lukáš Lacina is an academic researcher from First Faculty of Medicine, Charles University in Prague. The author has contributed to research in topics: Melanoma & Cancer. The author has an hindex of 21, co-authored 58 publications receiving 1471 citations. Previous affiliations of Lukáš Lacina include Charles University in Prague & Agency for Science, Technology and Research.
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Journal ArticleDOI
Germline NLRP1 Mutations Cause Skin Inflammatory and Cancer Susceptibility Syndromes via Inflammasome Activation
Franklin L. Zhong,Ons Mamaï,Lorenzo Sborgi,Lobna Boussofara,Richard Hopkins,Kim S. Robinson,Ildikó Szeverényi,Takuya Takeichi,Takuya Takeichi,Reshmaa Balaji,Aristotle Lau,Hazel Tye,Hazel Tye,Keya Roy,Carine Bonnard,Patricia J. Ahl,L. A. Jones,Paul J. Baker,Paul J. Baker,Lukáš Lacina,Atsushi Otsuka,Pierre Fournié,François Malecaze,E. Birgitte Lane,Masashi Akiyama,Kenji Kabashima,Kenji Kabashima,John E. Connolly,Seth L. Masters,Seth L. Masters,Vincent Soler,Salma Samir Omar,John A. McGrath,Roxana Ioana Nedelcu,Moez Gribaa,Mohamed Denguezli,Ali Saad,Sebastian Hiller,Bruno Reversade +38 more
TL;DR: It is found that germline mutations in the inflammasome sensor NLRP1 cause two overlapping skin disorders: multiple self-healing palmoplantar carcinoma (MSPC) and familial keratosis lichenoides chronica (FKLC) and the first genetic evidence linkingNLRP1 to skin inflammatory syndromes and skin cancer predisposition is provided.
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Melanoma cells influence the differentiation pattern of human epidermal keratinocytes
Ondřej Kodet,Lukáš Lacina,Lukáš Lacina,Eliska Krejci,Barbora Dvořánková,Milos Grim,Jiří Štork,Daniela Kodetova,Čestmír Vlček,Jana Šáchová,Michal Kolář,Hynek Strnad,Karel Smetana +12 more
TL;DR: It is concluded that the MC are able to influence locally the differentiation pattern of keratinocytes in vivo as well as in vitro, which highlights the role of intercellular interactions in melanoma.
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Ageing as an Important Risk Factor for Cancer
TL;DR: Data is summarized about the possible molecular mechanism influencing rapid spreading of tumors in the elderly population and the role of cancer stroma in controlling multiple biological properties of tumors is a prospective target for translational research with potential therapeutic outcomes.
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Simultaneous blocking of IL-6 and IL-8 is sufficient to fully inhibit CAF-induced human melanoma cell invasiveness.
Njainday Pulo Jobe,Daniel Rösel,Barbora Dvořánková,Ondřej Kodet,Lukáš Lacina,Rosana Mateu,Karel Smetana,Jan Brábek +7 more
TL;DR: Analysis of the role of IL-6 and IL-8 in CAF-induced melanoma invasion, using neutralising antibodies, revealed that simultaneous blocking of IL/IL-8 is sufficient to fully inhibit CAf-induced human melanoma cell invasiveness.
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Upregulation of IL-6, IL-8 and CXCL-1 production in dermal fibroblasts by normal/malignant epithelial cells in vitro: Immunohistochemical and transcriptomic analyses.
Michal Kolář,Pavol Szabo,Pavol Szabo,Barbora Dvořánková,Barbora Dvořánková,Lukáš Lacina,Lukáš Lacina,Hans-Joachim Gabius,Hynek Strnad,Jana Šáchová,Čestmír Vlček,Jan Plzak,Martin Chovanec,Zdeněk Čada,Jan Betka,Zdeněk Fík,Jan Pačes,Hana Kovářová,Jan Motlik,Karla Jarkovska,Karel Smetana +20 more
TL;DR: Considering an analogy between wound healing and tumour progression, chemokine and cytokine transcription and expression in normal fibroblasts is studied by co‐culture and in situ.