IgG4-related disease is an immune-mediated chronic, systemic, and autoinflammatory disease that can affect various organs throughout the body. The most commonly affected areas are the pancreas and biliary system. Due to the diverse clinical manifestations of the disease, it affects widely distributed organs. Thus, it is often easy to misdiagnose or miss. The digestive tract is a rarely affected system, and most IgG4-related gastric diseases manifest as tumors detected by endoscopy. This article reports two special cases with IgG4-related disease involving atrophic gastritis and intestinal polyps to provide a more empirical and theoretical basis for clinical diagnosis and treatment.

https://www.frontiersin.org/articles/10.3389/fimmu.2022.816830/pdf

IgG4-Related Disease With Gastrointestinal Involvement: Case Reports and Literature Review

Gastric IgG4‐related disease (IgG4‐RD) can mimic malignancy, submucosal tumors (SMT), and ulcers, leading to over‐triage and unnecessary medical interventions such as gastrectomy. The variability in the clinicopathological presentation of IgG4‐related disease is not yet well defined, posing a diagnostic challenge.

Min Ji Cho

Papers

Immunoglobulin G4-related disease in the stomach presenting as a gastric subepithelial tumor: Case report.