M
Ming Hong Shen
Researcher at University of Wales
Publications - 5
Citations - 438
Ming Hong Shen is an academic researcher from University of Wales. The author has contributed to research in topics: Exon & Mutation. The author has an hindex of 5, co-authored 5 publications receiving 420 citations.
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Journal ArticleDOI
Molecular genetics of neurofibromatosis type 1 (NF1).
TL;DR: The identification of somatic mutations in NF1 from tumour tissues strongly supports the speculation that NF1 is a member of the tumour suppressor gene family.
Journal ArticleDOI
Analysis of mutations at the neurofibromatosis 1 (NF1) locus.
Meena Upadhyaya,Ming Hong Shen,A. Cherryson,J. Farnham,Julie Helen Maynard,S.M. Huson,Peter S. Harper +6 more
TL;DR: A panel of 200 unrelated NF1 individuals has been screened for mutations using a panel of specific clones for the entire gene and no evidence of clustering of such mutations in the gene is found.
Journal ArticleDOI
Neurofibromatosis type 1 (NF1): the search for mutations by PCR-heteroduplex analysis on Hydrolink gels
TL;DR: 8 sets of new primers are used to amplify sequences throughout the NF1 gene, including 10 different exons and their flanking intron sequences, finding three novel mutations that should be useful for the further elucidation of the molecular basis of NF1.
Journal ArticleDOI
A de novo nonsense mutation in exon 28 of the neurofibromatosis type l (NF1) gene
Ming Hong Shen,Meena Upadhyaya +1 more
TL;DR: The authors have screened a total of 105 unrelated patients with neurofibromatosis type l for mutations in exon 28 of the NF1 gene using heteroduplex analysis and single strand conformation polymorphism analysis and identified one novel mutation.
Journal ArticleDOI
Two single base polymorphisms in introns 41 and 16 of the NF1 gene
Ming Hong Shen,Meena Upadhyaya +1 more
TL;DR: Two intragenic polymorphisms in the neurofibromatosis type 1 (NF1) gene are characterized by direct sequencing of PCR products and should assist in genetic analysis of NF1 families.