Ming-Xia Song

TL;DR: Four novel series of compounds, including the l-phenylalanine-derived C5-substituted rhodanine (6a-q, 7a-j) and chalcone derivatives containing thiobarbituric acid or 2-thioxo-4-thiazolidinone (9a-e, 11a- e) have been designed, synthesized, characterized, and evaluated for their antibacterial activity.

TL;DR: The studies suggest that rhodanine-based 5-aryloxy pyrazoles are interesting scaffolds for the development of novel Gram-positive antibacterial agents.

TL;DR: Five series of (Z)-5-(4-(2-oxo-2-phenylethoxy)benzylidene)-2-thioxothiazolidin-4-one derivatives (I-V) showed potent inhibition against several Gram-positive bacteria (including multidrug-resistant clinical isolates) with MIC values in the range of 1-32 μg/mL.

TL;DR: Three series of rhodanine derivatives bearing a quinoline moiety are suggested to be interesting scaffolds for the development of novel Gram-positive antibacterial agents.

TL;DR: 7-octyloxy-triazolo-[3, 4-b]benzo[d]thiazole (5g) was found to be the most potent compound with a median effective dose (ED(50)) value of 8.0 mg/kg and a protective index value of 15.0, possessing better anticonvulsant activity and higher safety than marketed drugs carbamazepine and phenytoin.