M
Mingchun Ji
Researcher at Yangzhou University
Publications - 18
Citations - 229
Mingchun Ji is an academic researcher from Yangzhou University. The author has contributed to research in topics: Interleukin 21 & Interleukin 12. The author has an hindex of 9, co-authored 18 publications receiving 200 citations.
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Ex vivo expansion of natural killer cells with high cytotoxicity by K562 cells modified to co-express major histocompatibility complex class I chain-related protein A, 4-1BB ligand, and interleukin-15.
TL;DR: The results indicated that K562-MICA-4-1BBL-IL-15 cells would be developed for expansion of NK cells ex vivo and may have important implications for clinical immunotherapy.
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Human fused NKG2D-IL-15 protein controls xenografted human gastric cancer through the recruitment and activation of NK cells.
Chen Yan,Bei Chen,Ti Yang,Weiming Xiao,Li Qian,Yanbing Ding,Mingchun Ji,Xiaoqun Ge,Weijuan Gong +8 more
TL;DR: The potential use of human dsNKG2D–IL-15 for tumor therapy is highlighted as it exhibited higher efficiency than IL-15 in suppressing gastric cancer growth and delayed the growth of transplanted melanoma by activating and recruiting mouse NK and CD8+ T cells.
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Neisseria gonorrhoeae NspA Induces Specific Bactericidal and Opsonic Antibodies in Mice
Guocai Li,Hongmei Jiao,Gui-hua Jiang,Jing Wang,Litian Zhu,Rushan Xie,Hua Yan,Hongju Chen,Mingchun Ji +8 more
TL;DR: Enzyme-linked immunosorbent assays indicated that all immunized mice generated measurable NspA-specific IgG and IgA in serum and secretory IgA (sIgA) in vaginal wash fluids, which demonstrated that NSpA induced antibodies with antigonococcal activity.
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Establishment and characterization of a cell based artificial antigen-presenting cell for expansion and activation of CD8+ T cells ex vivo.
Weijuan Gong,Mingchun Ji,Zhengfeng Cao,Li-Heng Wang,Ya-Yun Qian,Maozhi Hu,Li Qian,Xingyuan Pan +7 more
TL;DR: This approach was robust, simple, reproducible and economical for expansion and activation of CD8+ T cells and may have important therapeutic implications for adoptive immunotherapy.
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CD4+ NKG2D+ T cells induce NKG2D down‐regulation in natural killer cells in CD86‐RAE‐1ε transgenic mice
Zhijie Lin,Chang-rong Wang,Haizui Xia,Weiguang Liu,Weiming Xiao,Li Qian,Xiaoqin Jia,Yanbing Ding,Mingchun Ji,Weijuan Gong +9 more
TL;DR: The binding of NKG2D to its ligands strengthens the cross‐talk between natural killer cells and dendritic cells, particularly at early stages, before the initiation of the adaptive immune response.