M
Mingjian Shi
Researcher at Vanderbilt University Medical Center
Publications - 39
Citations - 1479
Mingjian Shi is an academic researcher from Vanderbilt University Medical Center. The author has contributed to research in topics: Medicine & Guanine nucleotide exchange factor. The author has an hindex of 18, co-authored 32 publications receiving 1254 citations. Previous affiliations of Mingjian Shi include Meharry Medical College & Vanderbilt University.
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Journal ArticleDOI
Recreating blood-brain barrier physiology and structure on chip: A novel neurovascular microfluidic bioreactor
Jacquelyn A. Brown,Virginia Pensabene,Dmitry A. Markov,Vanessa Allwardt,M. Diana Neely,Mingjian Shi,Clayton M. Britt,Orlando S. Hoilett,Qing Yang,Bryson M. Brewer,Philip C. Samson,Lisa J. McCawley,James M. May,Donna J. Webb,Deyu Li,Aaron B. Bowman,Ronald S. Reiserer,John P. Wikswo +17 more
TL;DR: The NVU has enabled in vitro modeling of the BBB using all human cell types and sampling effluent from both sides of the barrier, and has been validated with both fluorescein isothiocyanate-dextran diffusion and transendothelial electrical resistance.
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Retardation of Atherosclerosis by Overexpression of Catalase or Both Cu/Zn-Superoxide Dismutase and Catalase in Mice Lacking Apolipoprotein E
Hong Yang,L. Jackson Roberts,Mingjian Shi,Li Chun Zhou,Billy R. Ballard,Arlan Richardson,Arlan Richardson,Zhong Mao Guo +7 more
TL;DR: Observations implied that endogenously produced hydrogen peroxide, but not superoxide anions, contributed to the formation of oxidized lipids and the development of atherosclerosis in ApoE−/− mice.
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Metabolic consequences of inflammatory disruption of the blood-brain barrier in an organ-on-chip model of the human neurovascular unit
Jacquelyn A. Brown,Simona G. Codreanu,Mingjian Shi,Stacy D. Sherrod,Dmitry A. Markov,M. Diana Neely,M. Diana Neely,Clayton M. Britt,Orlando S. Hoilett,Ronald S. Reiserer,Philip C. Samson,Lisa J. McCawley,Donna J. Webb,Aaron B. Bowman,John A. McLean,John P. Wikswo +15 more
TL;DR: This study pairs a novel dual-chamber, organ-on-chip microfluidic device with small-volume cytokine detection and mass spectrometry analysis to investigate how the blood-brain barrier responds to two different but overlapping drivers of neuroinflammation, lipopolysaccharide and a cytokine cocktail of IL-1β, TNF-α, and MCP1,2.
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Glia Co-Culture with Neurons in Microfluidic Platforms Promotes the Formation and Stabilization of Synaptic Contacts
Mingjian Shi,Devi Majumdar,Yandong Gao,Bryson M. Brewer,Cody R. Goodwin,John A. McLean,Deyu Li,Donna J. Webb +7 more
TL;DR: Results show that communication between neurons and glia is critical for the formation and stability of synapses and point to the importance of developing neuron-glia co-culture systems such as the microfluidic platforms described in this study.
Journal ArticleDOI
The Anti-tumorigenic Properties of Peroxisomal Proliferator-activated Receptor α Are Arachidonic Acid Epoxygenase-mediated *
Ambra Pozzi,Ambra Pozzi,Vlad Popescu,Shilin Yang,Shaojun Mei,Mingjian Shi,Satu M. Puolitaival,Richard M. Caprioli,Jorge H. Capdevila +8 more
TL;DR: The identification of anti-angiogenic/anti-tumorigenic properties of PPARα points to a role for the receptor and its epoxygenase regulatory target in the pathophysiology of cancer, and for its ligands as candidates for the development of a new generation of safer and better tolerated anti-cancer drugs.