Mingli Qu

TL;DR: The results suggest that SP-NK-1 receptor signaling plays a critical role in the maintenance of corneal epithelium homeostasis, and that SP signaling through the NK-1 receptors contributes to the promotion of diabetic corneAL epithelial wound healing by rescued activation of Akt, EGFR, and Sirt1, improvement of mitochondrial function, and increased ROS scavenging capacity.

TL;DR: Macrophage depletion significantly impairs wound healing after autologous corneal transplantation through at least partially impacting on angiogenesis and wound closure.

TL;DR: This study provides the first evidence implicating that TSA inhibits TGF-β–induced ROS accumulation and myofibroblast differentiation via enhanced Nrf2-ARE signaling.

TL;DR: Rho-associated coiled-coil kinase (ROCK) inhibitor Y-27632 increased the cloning efficiency of rabbit limbal stem/progenitor cells by improving their adherence and ROS scavenging capacity.

TL;DR: TGFβ suppressed the production of proinflammatory factors and enhanced the expression of matrix remodeling genes of corneal fibroblasts in the transition from the proinflammatory state to the profibrotic state, and the dual roles of TGFβ on the phenotype regulations of cornea fibro Blasts were mediated by altered histone acetylation.