M
Mira Jung
Researcher at Georgetown University
Publications - 114
Citations - 4398
Mira Jung is an academic researcher from Georgetown University. The author has contributed to research in topics: Histone deacetylase & Ataxia-telangiectasia. The author has an hindex of 38, co-authored 105 publications receiving 4221 citations. Previous affiliations of Mira Jung include Georgetown University Medical Center.
Papers
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Journal ArticleDOI
Tissue ischemia time affects gene and protein expression patterns within minutes following surgical tumor excision.
Annika Spruessel,Garnet Steimann,Mira Jung,Sung A. Lee,Theresa Carr,Anne-Kristin Fentz,Joerg Spangenberg,Carsten Zornig,Hartmut Juhl,Kerstin David +9 more
TL;DR: In conclusion, preanalytical factors, such as tissue ischemia time, dramatically affect molecular data and control of these variables is mandatory to obtain reliable data in screening programs for molecular targets and diagnostic molecular patterns.
Journal ArticleDOI
Correction of radiation sensitivity in ataxia telangiectasia cells by a truncated I kappa B-alpha
TL;DR: Results suggest that aberrant regulation of NF-kappa B and I kappa B-alpha contribute to the cellular defect in AT.
Patent
Histone deacetylase inhibitors
TL;DR: In this paper, novel histone deacetylase inhibitors, including novel fluorescent HDE inhibitors, are described, and methods for making and using the same, e.g., to treat cancer, are provided.
Journal ArticleDOI
Mullerian inhibiting substance inhibits breast cancer cell growth through an NFκB-mediated pathway
Dorry L. Segev,Thanh U. Ha,Trinh T. Tran,Mary K. Kenneally,Paul Harkin,Mira Jung,David T. MacLaughlin,Patricia K. Donahoe,Shyamala Maheswaran +8 more
TL;DR: The results identify the NFκB-mediated signaling pathway and a target gene for MIS action and suggest a putative role for the MIS ligand and its downstream interactors in the treatment of ER-positive as well as negative breast cancers.
Journal ArticleDOI
A novel ionizing radiation-induced signaling pathway that activates the transcription factor NF-κB
TL;DR: Support is provided for a novel ionizing radiation-induced signaling pathway for activation of NF-κB and a molecular basis for the sensitivity of AT patients to oxidative stresses.