Miroslav Gottlieb

TL;DR: Results show that P2X7 purinergic receptors mediate tissue damage after OGD in neurons and following transient brain ischemia, therefore, these receptors are a relevant molecular target for the development of new treatments to attenuate brain damage following stroke.

TL;DR: A modified method of silver staining for native and denatured eucaryotic DNA in 1% agarose gel is described, which is at least fivefold more sensitive than ethidium bromide staining, especially advantageous for electrophoretic assessment of DNA molecular weights.

TL;DR: It is confirmed that postconditioning if used at right time and with optimal intensity can prevent process of delayed neuronal death, and protective impact of post conditioning in less-sensitive neuronal populations is very good after such a damaging insult like 15 min ischemia.

TL;DR: It seems that the mechanisms of ischemic tolerance‐delayed postconditioning could be used not only after ischemia but also in some other processes leading to apoptosis, since pre‐ or post‐conditioners can be used plenty of harmful stimuli and some physiological compounds, such as norepinephrine, bradykinin.

TL;DR: The results suggest that endogenous antioxidants SOD and CAT could play considerable neuroprotective role after postconditioning and it is interesting that the greatest changes were established in selectively vulnerable hippocampus and striatum.