M
Mitchell S. Nobler
Researcher at Columbia University
Publications - 52
Citations - 3914
Mitchell S. Nobler is an academic researcher from Columbia University. The author has contributed to research in topics: Electroconvulsive therapy & Dysthymic Disorder. The author has an hindex of 28, co-authored 52 publications receiving 3732 citations. Previous affiliations of Mitchell S. Nobler include New Generation University College & New York Medical College.
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Journal ArticleDOI
A prospective, randomized, double-blind comparison of bilateral and right unilateral electroconvulsive therapy at different stimulus intensities.
Harold A. Sackeim,Joan Prudic,Devangere P. Devanand,Mitchell S. Nobler,Sarah H. Lisanby,Shoshana Peyser,Linda Fitzsimons,Bobba J. Moody,Jenifer Clark +8 more
TL;DR: Right unilateral ECT at high dosage is as effective as a robust form of BL ECT, but produces less severe and persistent cognitive effects.
Journal ArticleDOI
Effects of Pulse Width and Electrode Placement on the Efficacy and Cognitive Effects of Electroconvulsive Therapy
Harold A. Sackeim,Joan Prudic,Mitchell S. Nobler,Linda Fitzsimons,Sarah H. Lisanby,Nancy A. Payne,Robert M. Berman,Eva-Lotta Brakemeier,Tarique D. Perera,Devangere P. Devanand +9 more
TL;DR: The use of an ultrabrief stimulus markedly reduces adverse cognitive effects, and when coupled with markedly suprathreshold right unilateral ECT, also preserves efficacy.
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Decreased Regional Brain Metabolism After ECT
Mitchell S. Nobler,Maria A. Oquendo,Lawrence S. Kegeles,Kevin M. Malone,Carl Campbell,Harold A. Sackeim,J. John Mann +6 more
TL;DR: Widespread regions of decreased regional cerebral glucose metabolism were identified after ECT, especially in the frontal and parietal cortex, anterior and posterior cingulate gyrus, and left temporal cortex.
Journal ArticleDOI
Regional Cerebral Blood Flow in Mood Disorders, III: Treatment and Clinical Response
Mitchell S. Nobler,Harold A. Sackeim,Isak Prohovnik,James R. Moeller,Sukdeb Mukherjee,David B. Schnur,Joan Prudic,Devangere P. Devanand +7 more
TL;DR: The findings indicated that cerebral blood flow abnormalities in major depression were not reversed by successful treatment with ECT, rather, particularly in responders, ECT resulted in additional perfusion reductions.
Journal ArticleDOI
EEG manifestations during ECT : effects of electrode placement and stimulus intensity
Mitchell S. Nobler,Harold A. Sackeim,Maria Solomou,Bruce Luber,Devangere P. Devanand,Joan Prudic +5 more
TL;DR: It is found that specific features of the ictal and immediate postictal EEG varied significantly with ECT stimulus intensity and electrode placement, and this indicates that seizure duration is not a useful marker of therapeutic efficacy, and provides preliminary evidence that other features ofThe EEG may be more useful markers of treatment adequacy.