M
Mitsuhiro Otani
Researcher at Sumitomo Chemical
Publications - 2
Citations - 11
Mitsuhiro Otani is an academic researcher from Sumitomo Chemical. The author has contributed to research in topics: Protoporphyrinogen oxidase & Heme. The author has an hindex of 1, co-authored 2 publications receiving 4 citations.
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Molecular dynamics mechanism to generate species differences in inhibition of protoporphyrinogen oxidase by flumioxazin
TL;DR: MD simulations of human, rat, and rabbit PPO–flumioxazin complexes found that rat PPO exhibited a higher binding affinity of flumoxazin than human and Rabbit PPOs, supporting the involvement of an MD mechanism in species differences in flumioxazer sensitivity.
Journal ArticleDOI
Different effects of an N-phenylimide herbicide on heme biosynthesis between human and rat erythroid cells.
Satoshi Kawamura,Mitsuhiro Otani,Taiki Miyamoto,Jun Abe,Ryo Ihara,Kunifumi Inawaka,Alan G. Fantel +6 more
TL;DR: It is suggested that the rat would be an inappropriate model for assessing the developmental toxicity of S-53482 in humans as rats are specifically sensitive to PPO inhibition by the herbicide.