Journal ArticleDOI
Different effects of an N-phenylimide herbicide on heme biosynthesis between human and rat erythroid cells.
Satoshi Kawamura,Mitsuhiro Otani,Taiki Miyamoto,Jun Abe,Ryo Ihara,Kunifumi Inawaka,Alan G. Fantel +6 more
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TLDR
It is suggested that the rat would be an inappropriate model for assessing the developmental toxicity of S-53482 in humans as rats are specifically sensitive to PPO inhibition by the herbicide.About:
This article is published in Reproductive Toxicology.The article was published on 2021-01-01. It has received 3 citations till now. The article focuses on the topics: Heme & Protoporphyrin IX.read more
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Flumioxazin, a PPO inhibitor: A weight-of-evidence consideration of its mode of action as a developmental toxicant in the rat and its relevance to humans.
Katsumasa Iwashita,Yoshinori Hosokawa,Ryosuke Ihara,Taiki Miyamoto,Mitsuhiro Otani,Jun Abe,Koji Asano,Odile Mercier,Kaori Miyata,Susan Barlow +9 more
TL;DR: A 3-dimensional molecular simulation revealed that species differences in binding affinity of flumioxazin to PPO, observed previously in vitro, were due to differences in the binding free energy as mentioned in this paper .
Journal ArticleDOI
Lack of human relevance for rat developmental toxicity of flumioxazin is revealed by comparative heme synthesis assay using embryonic erythroid cells derived from human and rat pluripotent stem cells.
Koji Asano,Yasuhiko Takahashi,M. Ueno,Takako Fukuda,Mitsuhiro Otani,Sachiko Kitamoto,Yoshitaka Tomigahara +6 more
TL;DR: It is demonstrated that there are no concerns in humans regarding the developmental toxicity of flumioxazin observed in rats, and flumoxazin has no effect on heme synthesis in human embryonic erythroid cells.
Journal ArticleDOI
Prediction of the human pharmacokinetics of epyrifenacil and its major metabolite, S-3100-CA, by a physiologically based pharmacokinetic modeling using chimeric mice with humanized liver.
TL;DR: In this paper , a physiologically-based pharmacokinetic (PBPK) model was developed to predict human internal dosimetry of S-3100-CA (CA).
References
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Human chronic myelogenous leukemia cell-line with positive Philadelphia chromosome.
TL;DR: This CML cell-line represents a unique source of CML cells with meaningful indicators of malignancy for clinical and experimental studies.
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Induction of erythroid differentiation in the human leukaemia cell line K562
TL;DR: It is reported that human leukaemic cells of the K562 cell line can be induced to red cell differentiation in vitro.
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Biosynthesis of heme in mammals
TL;DR: The biochemistry, structural biology and the mechanisms of tissue-specific regulation are presented in this review along with the key features of the porphyric disorders.
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Primitive and definitive erythropoiesis in mammals
TL;DR: Flow cytometry-based methodologies, developed to purify murine and human stage-specific erythroid precursors, have enabled comparative global gene expression studies and are providing new insights into the biology of erystroid maturation.
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Isolation and functional characterization of human erythroblasts at distinct stages: implications for understanding of normal and disordered erythropoiesis in vivo
Jingping Hu,Jingping Hu,Jing Liu,Jing Liu,Fumin Xue,Gregory R. Halverson,Marion E. Reid,Anqi Guo,Lixiang Chen,Azra Raza,Naomi Galili,Julie Jaffray,Joseph M. Lane,Joel Anne Chasis,Naomi Taylor,Narla Mohandas,Xiuli An,Xiuli An +17 more
TL;DR: By examining the dynamic changes of expression of membrane proteins during in vitro human terminal erythroid differentiation, band 3 and α4 integrin are identified as optimal surface markers for isolating 5 morphologically distinct populations at successive developmental stages and should facilitate a comprehensive cellular and molecular characterization of each specific developmental stage of human erythroblasts.