M
Mitsuyasu Nakamura
Researcher at University of Texas Medical Branch
Publications - 2
Citations - 1247
Mitsuyasu Nakamura is an academic researcher from University of Texas Medical Branch. The author has contributed to research in topics: NS3 & Signal transducing adaptor protein. The author has an hindex of 2, co-authored 2 publications receiving 1203 citations.
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Journal ArticleDOI
Immune evasion by hepatitis C virus NS3/4A protease-mediated cleavage of the Toll-like receptor 3 adaptor protein TRIF
Kui Li,Eileen Foy,Josephine C. Ferreon,Mitsuyasu Nakamura,Allan Chris M. Ferreon,Masanori Ikeda,Stuart C. Ray,Michael Gale,Stanley M. Lemon +8 more
TL;DR: It is shown that the NS3/4A serine protease of hepatitis C virus (HCV) causes specific proteolysis of Toll-IL-1 receptor domain-containing adaptor inducing IFN-beta (TRIF or TICAM-1), an adaptor protein linking TLR3 to kinases responsible for activating IFN regulatory factor 3 (IRF-3) and NF-kappaB, transcription factors controlling a multiplicity of antiviral defenses.
Journal ArticleDOI
Down-regulation of the retinoblastoma tumor suppressor by the hepatitis C virus NS5B RNA-dependent RNA polymerase
TL;DR: It is shown that Rb abundance is negatively regulated in cells containing replicating genomic RNA from hepatitis C virus, a human virus strongly associated with hepatocellular carcinoma, suggesting a unique link between an oncogenic RNA virus implicated in the development of liver cancer and a critically important tumor-suppressor protein.