Mladen Knotek

TL;DR: Among all patients with AOCLF, extracorporeal liver support with FPSA does not increase the probability of survival, and further studies are needed to assess whether therapy might be beneficial in specific subsets of patients.

TL;DR: A role of TNF is demonstrated in the early renal dysfunction in a septic mouse model independent of iNOS, hypotension, apoptosis, leukocyte accumulation, and morphological alterations, thus suggesting renal hypoperfusion secondary to an imbalance between, as yet to be defined, renal vasoconstrictors and vasodilators.

TL;DR: In conclusion, kidneys of iNOS knockout mice were protected against ischemic acute renal failure and this protective effect may be related to a compensatory upregulation of heat shock protein 72.

TL;DR: Results indicate that nNOS-derived NO contributes to the development of the hyperdynamic circulation and fluid retention in cirrhosis.

TL;DR: It is suggested that the hyperdynamic circulation and glomerular hyperfiltration of normal rat midterm pregnancy can be chronically reversed by NOS inhibition, and a role for endothelial damage and decreased NO in the pathogenesis of preeclampsia is suggested.