Mohammed Ahmed Rashid

TL;DR: This is the first systematic analysis showing EpCAM expression and CTC detection in NETs and seems to be associated with progressive disease and may provide useful prognostic information given the variable survival rates in these tumors.

TL;DR: The authors' biomarker algorithm provides novel insights into the cell-cycle state of dynamic tumour cell populations in vivo, of major prognostic significance and may impact on individualised therapeutic decisions.

TL;DR: Findings show that Cdc7 kinase predicts survival and is a potent anticancer target in epithelial ovarian carcinoma, highlighting its potential as a predictor of susceptibility to small molecule kinase inhibitors currently in development.

TL;DR: Radiolabelled DARPin (HE)3-G3 is a versatile radioligand with potential to allow the acquisition of whole-body HER2 scans on the day of administration and demonstrated that radioactivity from 111In-(HE) 3-G 3 was better maintained in tumours and cleared faster from serum thanRadioactivity from 125I-(HE), achieving superior tumour-to-blood ratios.

TL;DR: In this article, the cell-cycle protein Cdc7 regulates S phase by promoting DNA replication, which is an attractive therapeutic target for triple-receptor negative and Her2-overexpressing breast cancer.