M
Mohd Rehan
Researcher at King Abdulaziz University
Publications - 36
Citations - 567
Mohd Rehan is an academic researcher from King Abdulaziz University. The author has contributed to research in topics: Docking (molecular) & Virtual screening. The author has an hindex of 10, co-authored 36 publications receiving 334 citations.
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Journal ArticleDOI
Anticancer compound plumbagin and its molecular targets: a structural insight into the inhibitory mechanisms using computational approaches.
Mohammad Sarwar Jamal,Shadma Parveen,Mohd A. Beg,Mohd Suhail,Adeel G. Chaudhary,Ghazi A. Damanhouri,Adel M. Abuzenadah,Mohd Rehan +7 more
TL;DR: This first attempt to provide structural insights into the binding mode of plumbagin to five cancer signaling proteins viz.
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Spontaneous preterm birth and single nucleotide gene polymorphisms: a recent update.
Ishfaq A. Sheikh,Ejaz Ahmad,Mohammad Sarwar Jamal,Mohd Rehan,Mourad Assidi,Iftikhar Aslam Tayubi,Samera F. AlBasri,Osama S. Bajouh,Rola Turki,Adel M. Abuzenadah,Ghazi A. Damanhouri,Mohd A. Beg,Mohammed Al-Qahtani +12 more
TL;DR: Understanding the complex genomic landscape of PTB needs high-throughput genome sequencing methods such as whole-exome sequencing and whole-genome sequencing approaches that will significantly enhance the understanding ofPTB.
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Androgen and Progesterone Receptors Are Targets for Bisphenol A (BPA), 4-Methyl-2,4-bis-(P-Hydroxyphenyl)Pent-1-Ene--A Potent Metabolite of BPA, and 4-Tert-Octylphenol: A Computational Insight.
Mohd Rehan,Ejaz Ahmad,Ishfaq A. Sheikh,Adel M. Abuzenadah,Ghazi A. Damanhouri,Osama S. Bajouh,Samera F. AlBasri,Mansour M. Assiri,Mohd A. Beg +8 more
TL;DR: These compounds have the potential to block or interfere in the binding of the endogenous native AR and PR ligands and, hence, resulting in dysfunction and better prediction of potential of xenobiotic molecules for disrupting AR- and PR-mediated pathways, thus, helping in design of less potent alternatives for commercial use.
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Computational insights into the inhibitory mechanism of human AKT1 by an orally active inhibitor, MK-2206.
TL;DR: The docking and (un)binding simulation analyses of MK-2206 with AKT isoforms and its structure analogs will provide a suitable model for studying drug-protein interaction and will help in designing better drugs.
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An Anti-Cancer Drug Candidate OSI-027 and its Analog as Inhibitors of mTOR: Computational Insights Into the Inhibitory Mechanisms.
TL;DR: Computational insights are presented into the OSI‐027 mediated inhibition of mTOR kinase and an OSi‐027 analog is proposed as better mTOR inhibitor, and thus, a good drug for further research in experimental laboratories.