Showing papers by "Moinak Banerjee published in 2008"
TL;DR: Although the eNOS polymorphisms were not found to be a likely risk factor for aSAH, the role of factors such as ethnicity, gender, smoking and hypertension should be evaluated cautiously to understand the genotype to phenotype conversion.
Abstract: Endothelial nitric oxide synthase (eNOS) gene polymorphisms have been implicated as predisposing genetic factors that can predict aneurysmal subarachnoid hemorrhage (aSAH), but with controversial results from different populations. Using a case-control study design, we tested the hypothesis whether variants in eNOS gene can increase risk of aSAH among South Indian patients, either independently, or by interacting with other risk factors of the disease. We enrolled 122 patients, along with 224 ethnically matched controls. We screened the intron-4 27-bp VNTR, the promoter T-786C and the exon-7 G894T SNPs in the eNOS gene. We found marked interethnic differences in the genotype distribution of eNOS variants when comparing the South Indian population with the reported frequencies from Caucasian and Japanese populations. Genotype distributions in control and patient populations were found to be in Hardy-Weinberg equilibrium. In patients, the allele, genotype and estimated haplotype frequencies did not differ significantly from the controls. Multiple logistic regression indicated hypertension and smoking as risk factors for the disease, however the risk alleles did not have any interaction with these risk factors. Although the eNOS polymorphisms were not found to be a likely risk factor for aSAH, the role of factors such as ethnicity, gender, smoking and hypertension should be evaluated cautiously to understand the genotype to phenotype conversion.
11 citations
TL;DR: This work demonstrates a novel, rapid and cost-effective method of making in-house 100bp ladder for routine use and can provide size standards for an endless usage.
4 citations
01 Jan 2008
TL;DR: A case study on Hyblaea demonstrates the efficiency of the barcoding gene (folmer region) in discriminating global phylogeographical variants among the Hy Blaea species complex.
Abstract: Hyblaea puera (teak defoliator) is a pest moth of teak woodlands in India and other tropics. H. puera is a type genus that represents the family Hyblaeidae and superfamily Hyblaeoidea. The relationships between the superfamily Hyblaeoidea other smaller superfamilies like Pyraloidea, Bombycoidea, Geometroidea, Noctuoidea, Torticoidea, Papilionoidea and others are not well understood. This study provides substantial molecular evidence in supporting the morphological classification of Hyblaeidae fam ily and its relationship with other superfamilies. As a molecular tool DNA barcoding has gained importance in species identification and taxonomic verification. Present case study on Hyblaea demonstrates the efficiency of the barcoding gene (folmer region) in discriminating global phylogeographical variants among the Hyblaea species complex.
TL;DR: Hyblaea puera (teak defoliator) is a pest moth of teak woodlands in India and other tropics as discussed by the authors, it is a type genus that represents the family Hyblaeidae and superfamily hyblaeoidea.
Abstract: Hyblaea puera (teak defoliator) is a pest moth of teak woodlands in India and other tropics H puera is a type genus that represents the family Hyblaeidae and superfamily Hyblaeoidea The relationships between the superfamily Hyblaeoidea other smaller superfamilies like Pyraloidea, Bombycoidea, Geometroidea, Noctuoidea, Torticoidea, Papilionoidea and others are not well understood This study provides substantial molecular evidence in supporting the morphological classification of Hyblaeidae family and its relationship with other superfamilies As a molecular tool DNA barcoding has gained importance in species identification and taxonomic verification Present case study on Hyblaea demonstrates the efficiency of the barcoding gene (folmer region) in discriminating global phylogeographical variants among the Hyblaea species complex