M
Monica C. Hollstein
Researcher at National Institutes of Health
Publications - 2
Citations - 8098
Monica C. Hollstein is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Mutation & Carcinogenesis. The author has an hindex of 2, co-authored 2 publications receiving 7938 citations. Previous affiliations of Monica C. Hollstein include International Agency for Research on Cancer.
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p53 mutations in human cancers
TL;DR: The p53 mutational spectrum differs among cancers of the colon, lung, esophagus, breast, liver, brain, reticuloendothelial tissues, and hemopoietic tissues as mentioned in this paper.
Journal ArticleDOI
Mutational Spectra and Immunohistochemical Analyses of p53 in Human Cancers
William P. Bennett,Monica C. Hollstein,Monica C. Hollstein,Ih-Chang Hsu,Ih-Chang Hsu,David Sidransky,David Sidransky,David P. Lane,David P. Lane,Bert Vogelstein,Bert Vogelstein,Curtis C. Harris +11 more
TL;DR: Gathering evidence supports the hypothesis that missense mutations occurring within the conserved regions ofthe p53 coding sequence induce conformational changes which extend the half-life of the p53 protein.