M
Monica Castiglione-Gertsch
Researcher at University of Bern
Publications - 81
Citations - 8920
Monica Castiglione-Gertsch is an academic researcher from University of Bern. The author has contributed to research in topics: Breast cancer & Tamoxifen. The author has an hindex of 44, co-authored 81 publications receiving 8489 citations. Previous affiliations of Monica Castiglione-Gertsch include European Institute of Oncology & Harvard University.
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Journal ArticleDOI
A comparison of letrozole and tamoxifen in postmenopausal women with early breast cancer
Beat Thürlimann,Aparna Keshaviah,Alan S. Coates,Henning T. Mouridsen,Louis Mauriac,John F. Forbes,Robert Paridaens,Monica Castiglione-Gertsch,Richard D. Gelber,Manuela Rabaglio,Ian E. Smith,Andrew M Wardley,Karen N. Price,Aron Goldhirsch +13 more
TL;DR: In postmenopausal women with endocrine-responsive breast cancer, adjuvant treatment with letrozole, as compared with tamoxifen, reduced the risk of recurrent disease, especially at distant sites.
Journal ArticleDOI
Five Years of Letrozole Compared With Tamoxifen As Initial Adjuvant Therapy for Postmenopausal Women With Endocrine-Responsive Early Breast Cancer: Update of Study BIG 1-98
Alan S. Coates,Aparna Keshaviah,Beat Thürlimann,Henning T. Mouridsen,Louis Mauriac,John F. Forbes,Robert Paridaens,Monica Castiglione-Gertsch,Richard D. Gelber,Marco Colleoni,István Láng,Lucia Del Mastro,Ian E. Smith,Jacquie Chirgwin,J.M. Nogaret,Tadeusz Pienkowski,Andrew M Wardley,Erik Jakobsen,Karen N. Price,Aron Goldhirsch +19 more
TL;DR: The present updated analysis, which was limited to patients on monotherapy arms in BIG 1-98, yields results similar to those from the previous primary analysis but more directly comparable with results from other trials of continuous therapy using a single endocrine agent.
Journal ArticleDOI
Role of immunohistochemical detection of lymph-node metastases in management of breast cancer
Richard J. Cote,H Fpeterson,Benjaporn Chaiwun,R. D. Gelber,A. Goldhirsch,Monica Castiglione-Gertsch,Barry A. Gusterson,A. M. Neville +7 more
TL;DR: The immunohistochemical examination of ipsilateral axillary lymph nodes is a reliable, prognostically valuable, and simple method for the detection of occult nodal metastases and is recommended as a standard method of node examination in postmenopausal patients.
Journal ArticleDOI
Prognostic and predictive value of centrally reviewed expression of estrogen and progesterone receptors in a randomized trial comparing letrozole and tamoxifen adjuvant therapy for postmenopausal early breast cancer: BIG 1-98
Giuseppe Viale,Meredith M. Regan,Eugenio Maiorano,Mauro G. Mastropasqua,Patrizia Dell'Orto,Birgitte Bruun Rasmussen,Johnny Raffoul,Patrick Neven,Zsolt Orosz,Stephen G. Braye,Christian Öhlschlegel,Beat Thürlimann,Richard D. Gelber,Monica Castiglione-Gertsch,Karen N. Price,Aron Goldhirsch,Barry A. Gusterson,Alan S. Coates +17 more
TL;DR: Central review changed the assessment of receptor status in a substantial proportion of patients, and should be performed whenever possible in similar trials.
Journal ArticleDOI
Identifying breast cancer patients at risk for Central Nervous System (CNS) metastases in trials of the International Breast Cancer Study Group (IBCSG)
Bernhard C. Pestalozzi,David Zahrieh,Karen N. Price,Stig Holmberg,J. Lindtner,John P. Collins,Diana Crivellari,Martin F. Fey,Elizabeth Murray,Olivia Pagani,Edda Simoncini,Monica Castiglione-Gertsch,Richard D. Gelber,Alan S. Coates,A. Goldhirsch +14 more
TL;DR: Using data from 9524 women with early breast cancer who were randomized in International Breast Cancer Study Group clinical trials between 1978 and 1999, a group at sufficient risk to justify routine screening for occult central nervous system metastases was not defined.