P
Patrizia Dell'Orto
Researcher at European Institute of Oncology
Publications - 86
Citations - 3859
Patrizia Dell'Orto is an academic researcher from European Institute of Oncology. The author has contributed to research in topics: Breast cancer & Tamoxifen. The author has an hindex of 32, co-authored 84 publications receiving 3416 citations. Previous affiliations of Patrizia Dell'Orto include University of Milan.
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Journal ArticleDOI
Prognostic and predictive value of centrally reviewed expression of estrogen and progesterone receptors in a randomized trial comparing letrozole and tamoxifen adjuvant therapy for postmenopausal early breast cancer: BIG 1-98
Giuseppe Viale,Meredith M. Regan,Eugenio Maiorano,Mauro G. Mastropasqua,Patrizia Dell'Orto,Birgitte Bruun Rasmussen,Johnny Raffoul,Patrick Neven,Zsolt Orosz,Stephen G. Braye,Christian Öhlschlegel,Beat Thürlimann,Richard D. Gelber,Monica Castiglione-Gertsch,Karen N. Price,Aron Goldhirsch,Barry A. Gusterson,Alan S. Coates +17 more
TL;DR: Central review changed the assessment of receptor status in a substantial proportion of patients, and should be performed whenever possible in similar trials.
Journal ArticleDOI
Prognostic and Predictive Value of Centrally Reviewed Ki-67 Labeling Index in Postmenopausal Women With Endocrine-Responsive Breast Cancer: Results From Breast International Group Trial 1-98 Comparing Adjuvant Tamoxifen With Letrozole
Giuseppe Viale,Anita Giobbie-Hurder,Meredith M. Regan,Alan S. Coates,Mauro G. Mastropasqua,Patrizia Dell'Orto,Eugenio Maiorano,Gaëtan MacGrogan,Stephen G. Braye,Christian Öhlschlegel,Patrick Neven,Zsolt Orosz,Wojciech P. Olszewski,F Knox,Beat Thürlimann,Karen N. Price,Monica Castiglione-Gertsch,Richard D. Gelber,Barry A. Gusterson,Aron Goldhirsch +19 more
TL;DR: Ki-67 LI is confirmed as a prognostic factor in this study and may identify a patient group that particularly benefits from initial Let adjuvant therapy in postmenopausal women with early breast cancer.
Journal ArticleDOI
CYP2D6 Genotype and Tamoxifen Response in Postmenopausal Women with Endocrine-Responsive Breast Cancer: The Breast International Group 1-98 Trial
Meredith M. Regan,Brian Leyland-Jones,Mark Bouzyk,Olivia Pagani,Weining Tang,Roswitha Kammler,Patrizia Dell'Orto,Maria Olivia Biasi,Beat Thürlimann,Maria Bibi Lyng,Henrik J. Ditzel,Patrick Neven,Marc Debled,Rudolf Maibach,Karen N. Price,Richard D. Gelber,Alan S. Coates,Aron Goldhirsch,James M. Rae,Giuseppe Viale,Giuseppe Viale +20 more
TL;DR: The results of this study do not support using the presence or absence of hot flushes or the pharmacogenetic testing of CYP2D6 to determine whether to treat postmenopausal breast cancer patients with tamoxifen and support the hypothesis that reduced enzyme activity was associated with worse disease control.
Journal ArticleDOI
Axillary dissection versus no axillary dissection in patients with breast cancer and sentinel-node micrometastases (IBCSG 23-01): 10-year follow-up of a randomised, controlled phase 3 trial.
Viviana Galimberti,Bernard F. Cole,Giuseppe Viale,Giuseppe Viale,Paolo Veronesi,Paolo Veronesi,Elisa Vicini,Mattia Intra,Giovanni Mazzarol,Samuele Massarut,Janez Zgajnar,Mario Taffurelli,David Littlejohn,Michael Knauer,Carlo Tondini,Angelo Di Leo,Marco Colleoni,Meredith M. Regan,Alan S. Coates,Richard D. Gelber,Aron Goldhirsch,Frances M. Boyle,Guy Jerusalem,Rolf A. Stahel,Stefan Aebi,Michael D. Green,Per Karlsson,Ingrid Kössler,István Láng,Anita Hiltbrunner,Jürg Bernhard,Stamatina Fournarakou,Roswitha Kammler,Rudolf Maibach,Manuela Rabaglio,Karin Ribi,Heidi Roschitzki,Susanne Roux,Barbara Ruepp,Caitlin Mahoney,Karen N. Price,Lynette Blacher,Tara Scolese,Karolyn Scott,Sandra Lippert,Theresa Zielinski,Mauro G. Mastropasqua,Stefania Andrighetto,Patrizia Dell'Orto,Giuseppe Renne,Giancarlo Pruneri,Silvia Dellapasqua,Monica Iorfida,Giuseppe Cancello,Emilia Montagna,Anna Cardillo,Giulia Peruzzotti,R. Ghisini,Alberto Luini,Umberto Veronesi,Oreste Gentilini,Stefano Zurrida,Giuseppe Curigliano,Franco Nolè,Roberto Orecchia,Marisa Cristina Leonardi,Paola Baratella,Camelia Chifu,Manuela Sargenti,Diana Crivellari,Sandro Morassut,Mario Mileto,Erica Piccoli,Andreas Veronesi,Marisa Donatella Magri,Angelo Buonadonna,Ezio Candiani,Antonino Carbone,Tiziana Perin,Rachele Volpe,Mario Roncadin,Mauro Arcicasa,Francesco Coran,Manuela Lagrassa,Angelo Recalcati,Maria Emanuela Limonta,Paolo Tricomi,Privato Fenaroli,Elisabetta Candiago,Laura Cattaneo,Alberto Gianatti,Donatella Santini,Sylvie Maweja,Philippe Delvenne,Andrée Rorive,Joëlle Collignon,Jean-Remi Garbay,Marie-Christine Mathieu,Hanne Galatius,Jack Hoffmann,Peer Schousen,Charlotte Lanng,John Hoerby,Birgitte Bruun Rasmussen,Helle Holtveg,Maj-Lis Moeller Talman,Julio Abugattas,Jose Manuel Cotrina,Richard Dyer,Jurij Lindtner,Elga Majdic,Snjezana Frkovic-Grazio,Christian Oehlschlegel,Gerhard Ries,Michael Töpfer,Ute Lorenz,Otto Schiltknecht,Bruno Späti,Andreas Ehrsam,Monika Bamert,Martina Egli-Tupaj,Christoph Rageth,Elisabeth Saurenmann,Christoph Tausch,Rosmarie Caduff,Holger Moch,Zsuzsanna Varga,Dimitri Sarlos,Elena Kralidis,Rainer Grobholz,Olivia Pagani,Lucia Bronz,Michele Ghielmini,Luca Mazzucchelli,Tiziana Rusca,Thomas Gyr,Linda Leidi,Giorgio Caccia,Daniel Wyss,Martin F. Fey,Michael Müller,Andreas Günthert,Gilles Berclaz,Achim Fleischmann,Jean Francois Delaloye,Assia Treboux,Hans-Anton Lehr,Maryse Fiche,L Perey,Lucien Zaman,Wendy Jeanneret Sozzi,John F. Forbes,D. F. Lindsay,D.F. Preece,Jane Hill,P. Jeal,P. Smart,John J. Collins,Gregory Bruce Mann,Robert Millar,Craig Murphy,Malcolm Buchanan,Anand Murugasu,James French,Elisabeth Elder,Lynette Mann,David Moon,A. Michael Bilous,Nirmala Pathmanathan,Virginia Howard,Petere G. Gill,James Kollias,Melissa Bochner,Linda Madigan,Elisabeth Rippy,Robert Whitfield,Fereshte Farshidi,Katrina Moore,Mark Sywak,L. Tan,William Ross,Karen Briscoe,Allison Jones,Aashit Shah,Elgene Lim,Robert Macindoe,Andrew J. Spillane,S. Fiona Bonar,Hugh Carmalt,Richard West,Cindy Mak,Paul McKenzie,Richard Harman,Susanne Gerred,Eva Juhasz,Stephen Allpress,Julie Craik,Ian G. Campbell,Paul Chin,Lori Hayes,Frederick Mayall,M. Thorburn +201 more
TL;DR: The findings of the IBCSG 23-01 trial corroborate those obtained at 5 years and are consistent with those of the 10-year follow-up analysis of the Z0011 trial, and support the current practice of not doing an axillary dissection when the tumour burden in the sentinel nodes is minimal or moderate.
Journal ArticleDOI
Adjuvant letrozole versus tamoxifen according to centrally-assessed ERBB2 status for postmenopausal women with endocrine-responsive early breast cancer: supplementary results from the BIG 1-98 randomised trial
Birgitte Bruun Rasmussen,Meredith M. Regan,Anne E. Lykkesfeldt,Patrizia Dell'Orto,Barbara Del Curto,Katrine L Henriksen,Mauro G. Mastropasqua,Karen N. Price,Eliane Méry,Magali Lacroix-Triki,Stephen G. Braye,Stephen G. Braye,Hans J Altermatt,Richard D. Gelber,Monica Castiglione-Gertsch,Aron Goldhirsch,Barry A. Gusterson,Beat Thürlimann,Alan S. Coates,Giuseppe Viale,Giuseppe Viale +20 more
TL;DR: The results of the Breast International Group (BIG) 1-98 trial as mentioned in this paper showed that letrozole significantly improved disease-free survival (DFS) compared with tamoxifen in postmenopausal women with endocrine-responsive early breast cancer.