M
Moo J. Cho
Researcher at University of North Carolina at Chapel Hill
Publications - 1
Citations - 275
Moo J. Cho is an academic researcher from University of North Carolina at Chapel Hill. The author has contributed to research in topics: Cytotoxicity & Efflux. The author has an hindex of 1, co-authored 1 publications receiving 253 citations.
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Doxorubicin and Paclitaxel-Loaded Lipid-Based Nanoparticles Overcome Multidrug Resistance by Inhibiting P-Glycoprotein and Depleting ATP
Xiaowei Dong,Cynthia Mattingly,Michael T. Tseng,Moo J. Cho,Yang Liu,Val R. Adams,Russell J. Mumper +6 more
TL;DR: Enhanced uptake and prolonged retention of doxorubicin were observed with nanoparticle-based formulations in P-gp-overexpressing cells, and injection of pegylated paclitaxel nanoparticles showed marked anticancer efficacy in nude mice bearing resistant NCI/ADR-RES tumors versus all control groups.