Motohiko Sato

TL;DR: It is shown that Cbfa1 is an important factor for chondrocyte differentiation, and the expression of PTH/PTHrP receptor, Indian hedgehog, type X collagen, and BMP6 was not detected in humerus and femur, indicating that chondrodynamic differentiation was blocked before prehypertrophic chondROcytes.

TL;DR: It is suggested that PEBP2αA and ETS1 cooperate in vivo to regulate expression of the opn gene in the skeletal tissue and the specific spatial arrangement of both sites and direct interaction between PEBP1 and Ets1, were essential for promoter function.

TL;DR: The present results suggest that excellent and uninterrupted bone formation during distraction osteogenesis owes to enhanced expression of B MP‐2 and BMP‐4 genes by mechanical tension‐stress.

TL;DR: The results indicate that these cells responded to mechanical stress loaded on the bone with expression of the osteopontin gene, and strongly suggests that OPN is an important factor triggering bone remodeling caused by mechanical stress.

TL;DR: At least three different modes of ossification during bone lengthening by distraction osteogenesis are found, including 'transchondroid bone formation', which was formed directly by chondrocyte-like cells, with transition from fibrous tissue to bone occurring gradually and consecutively without capillary invasion.