S
Seiichi Hirota
Researcher at Hyogo College of Medicine
Publications - 460
Citations - 17521
Seiichi Hirota is an academic researcher from Hyogo College of Medicine. The author has contributed to research in topics: GiST & Stromal tumor. The author has an hindex of 56, co-authored 432 publications receiving 16213 citations. Previous affiliations of Seiichi Hirota include Osaka University & Nara Medical University.
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Journal ArticleDOI
Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1
Takashi Nagasawa,Seiichi Hirota,Kazunobu Tachibana,Nobuyuki Takakura,Shin-Ichi Nishikawa,Yukihiko Kitamura,Nobuaki Yoshida,Hitoshi Kikutani,Tadamitsu Kishimoto +8 more
TL;DR: It is shown that the chemokine PBSF/SDF-1 has several essential functions in development, including B-cell lymphopoiesis and bone-marrow myelopoiedis and a cardiac ventricular septal defect.
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The chemokine receptor CXCR4 is essential for vascularization of the gastrointestinal tract.
Kazunobu Tachibana,Seiichi Hirota,Hisashi Iizasa,Hisahiro Yoshida,Kenji Kawabata,Yuki Kataoka,Yukihiko Kitamura,Kouji Matsushima,Nobuaki Yoshida,Shin-Ichi Nishikawa,Tadamitsu Kishimoto,Takashi Nagasawa +11 more
TL;DR: PBSF/SDF-1 and CXCR4 define a new signalling system for organ vascularization, and it is reported that CX CR4 is expressed in developing vascular endothelial cells, and that mice lacking CxCR4 or PBSF/ sdf-1 have defective formation of the large vessels supplying the gastrointestinal tract.
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Gain-of-function mutations of platelet-derived growth factor receptor α gene in gastrointestinal stromal tumors
Seiichi Hirota,Akiko Ohashi,Toshirou Nishida,Koji Isozaki,Kazuo Kinoshita,Yasuhisa Shinomura,Yukihiko Kitamura +6 more
TL;DR: The gain-of-function mutations of PDGFR alpha appear to play an important role in development of GISTs without KIT mutations.
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Familial gastrointestinal stromal tumours with germline mutation of the kit gene
Toshirou Nishida,Seiichi Hirota,Masahiko Taniguchi,Koji Hashimoto,Koji Isozaki,Harumi Nakamura,Yuzuru Kanakura,Tomoyuki Tanaka,Arimichi Takabayashi,Hikaru Matsuda,Yukihiko Kitamura +10 more
TL;DR: Familial gastrointestinal stromal tumours with germline mutation of the KIT gene is reported: affected members all have a KIT mutation occurring between the transmembrane and tyrosine kinase domains, which is also the region where mutations have been found in solitary GISTs
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Targeting of both mouse neuropilin-1 and neuropilin-2 genes severely impairs developmental yolk sac and embryonic angiogenesis
Seiji Takashima,Masafumi Kitakaze,Masanori Asakura,Hiroshi Asanuma,Shoji Sanada,Fumi Tashiro,Hitoshi Niwa,Jun-ichi Miyazaki,Seiichi Hirota,Yukihiko Kitamura,Takashi Kitsukawa,Hajime Fujisawa,Michael Klagsbrun,Masatsugu Hori +13 more
TL;DR: The results suggest that NRPs are early genes in embryonic vessel development and that both NP1 and NP2 are required.