https://pubs.rsc.org/en/Content/ArticlePDF/2016/GC/C5GC02500A

Review: nanocelluloses as versatile supports for metal nanoparticles and their applications in catalysis

Recent advances in multicomponent reactions for diversity-oriented synthesis

Multicomponent reactions have gained significant importance as a tool for the synthesis of a wide variety of useful compounds, including pharmaceuticals. In this context, the multiple component approach is especially appealing in view of the fact that products are formed in a single step, and the diversity can be readily achieved simply by varying the reacting components. The eco-friendly, solvent-free multicomponent approach opens up numerous possibilities for conducting rapid organic synthesis and functional group transformations more efficiently. Additionally, there are distinct advantages of these solvent-free protocols since they provide reduction or elimination of solvents thereby preventing pollution in organic synthesis “at source”. The chemo-, regio- or stereoselective synthesis of high-value chemical entities and parallel synthesis to generate a library of small molecules will add to the growth of multicomponent solvent-free reactions in the near future. In this review we summarized the results reported mainly within the last 10 years. It is quite clear from the growing number of emerging publications in this field that the possibility to utilize multicomponent technology allows reaction conditions to be accessed that are very valuable for organic synthesis. Therefore, diversity oriented synthesis (DOS) is rapidly becoming one of the paradigms in the process of modern drug discovery. This has spurred research in those fields of chemical investigation that lead to the rapid assembly of not only molecular diversity, but also molecular complexity. As a consequence multi-component as well as domino or related reactions are witnessing a new spring.

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Recent developments in solvent-free multicomponent reactions: a perfect synergy for eco-compatible organic synthesis

Metal-Free Multicomponent Syntheses of Pyridines

Heterocycles display an intrinsic reactivity which enables rich, versatile and productive transformations. Taking into account their ubiquitous presence in natural products and drugs, the development of new, fast and efficient preparative protocols for these structures remains an urgent task in Organic Synthesis. Multicomponent reactions using heterocyclic chemistry offer new possibilities to exploit this exclusive reactivity. Recent results show relevant examples of such transformations. Several approaches which allow the construction of complex heterocyclic compounds from simple starting materials using this principle have been analyzed.

Heterocycles as key substrates in multicomponent reactions: the fast lane towards molecular complexity.

One-pot, three-component route to 2H-indazolo[2,1-b]phthalazine-triones

Solvent-free synthesis of aryl-14H-dibenzo[a,j]xanthenes and 1,8-dioxo-octahydro-xanthenes using silica sulfuric acid as catalyst

A simple and efficient catalytic procedure for the synthesis of 14-aryl-14H-dibenzo[a,j]xanthene is reported. Tungsten heteropoly acid catalysts are used both in bulk or supported on silica gel under solvent-free conditions at 100 °C. Good yields and short reaction time are advantages of this new method.

Mozhdeh Seyyedhamzeh

Papers

One-pot, three-component route to 2H-indazolo[2,1-b]phthalazine-triones

Solvent-free synthesis of aryl-14H-dibenzo[a,j]xanthenes and 1,8-dioxo-octahydro-xanthenes using silica sulfuric acid as catalyst

Heteropolyacid: An efficient and eco-friendly catalyst for the synthesis of 14-aryl-14H-dibenzo[a,j]xanthene

A novel three-component method for the synthesis of triazolo(1,2-a)indazole-triones

Synthesis of fully substituted pyrazolo[3,4-b]pyridine-5-carboxamide derivatives via a one-pot four-component reaction