M
Mueller Richard H
Researcher at Bristol-Myers Squibb
Publications - 28
Citations - 472
Mueller Richard H is an academic researcher from Bristol-Myers Squibb. The author has contributed to research in topics: Hydroxymethyl & Triphenylphosphine. The author has an hindex of 10, co-authored 28 publications receiving 460 citations. Previous affiliations of Mueller Richard H include Princeton University & Eisai.
Papers
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Journal ArticleDOI
Conversion of L-pyroglutamic acid to 4-alkyl-substituted L-prolines. The synthesis of trans-4-cyclohexyl-L-proline
TL;DR: In this article, a transcyclohexyl-4 L-prolinol is transformed into trans-cyclo-hexyl]-4 Lproline via cyclo-3 cyclohexene reduction, on obtient l'on transforme ensuite ensuite en transcycloenyl-3 pyrrolo [1,2-c] oxazolone.
Journal ArticleDOI
Stereo- and regioselective total synthesis of the hydropyrido[2,1,6-de]quinolizine ladybug defensive alkaloids
TL;DR: Synthese des precoccinelline, hippodamine, hippocasine, leurs N-oxydes, de myrrhine, de propyleine and d'isopropyleine a partir de perhydro boraphenalene.
Patent
[(1-Alkoxy-1-methyl)-ethoxy]-amines, their preparation and their use for the preparation of 3-acylamino-1-hydroxy-2-azetidinones
TL;DR: In this paper, novel chemical compounds having the formula I and processes for using compounds of formula I to obtain compounds with the formula have been described. But they did not specify the properties of the compounds.
Journal ArticleDOI
A Practical Stereoselective Synthesis and Novel Cocrystallizations of an Amphiphatic SGLT-2 Inhibitor
Prashant P. Deshpande,Janak Singh,Annie Pullockaran,Thomas P. Kissick,Bruce A. Ellsworth,Jack Z. Gougoutas,John D. Dimarco,Michael Fakes,Mayra B. Reyes,Chiajen Lai,Hidegard Lobinger,Theo Denzel,Peter Hans Ermann,Gerard A. Crispino,Michael E. Randazzo,Zenrong Gao,Renee Randazzo,Mark Lindrud,Victor W. Rosso,Frederic G. Buono,Wendel W. Doubleday,Simon Leung,Pricilla Richberg,David Hughes,William N. Washburn,Wei Meng,Kevin J. Volk,Mueller Richard H +27 more
TL;DR: In this article, a practical synthesis of the SGLT-2 inhibitor β-C-aryl-d-glucoside (1) has been developed using 2,3,4,6-tetra-Otrimethlysilyl-dglucano-1,5-lactone as the key chiral building block, prepared efficiently from commercially available, inexpensive raw materials, d-gluconolactone and trimethylsilyl chloride.
Journal ArticleDOI
Regioselective Coupling of Tetraalkylammonium Salts of 6-Iodo-2-aminopurine to a Cyclobutyl Triflate: Efficient Preparation of Homochiral BMS-180,194, a Potent Antiviral Carbocyclic Nucleoside
Gregory S. Bisacchi,Janak Singh,Jollie D. Godfrey,Thomas P. Kissick,Toomas Mitt,Mary F. Malley,John D. Di Marco,Jack Z. Gougoutas,Mueller Richard H,Robert Zahler +9 more