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Mustafa Porsch-Özcürümez
Researcher at University of Regensburg
Publications - 9
Citations - 2502
Mustafa Porsch-Özcürümez is an academic researcher from University of Regensburg. The author has contributed to research in topics: ATP-binding cassette transporter & Promoter. The author has an hindex of 8, co-authored 9 publications receiving 2461 citations.
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Journal ArticleDOI
The gene encoding ATP-binding cassette transporter 1 is mutated in Tangier disease
Marek Bodzioch,Evelyn Orsó,Jochen Klucken,Thomas Langmann,Alfred Böttcher,Wendy Diederich,Wolfgang Drobnik,Stefan Barlage,Christa Büchler,Mustafa Porsch-Özcürümez,Wolfgang E. Kaminski,Harry W. Hahmann,Kurt Oette,Gregor Rothe,Charalampos Aslanidis,Karl J. Lackner,Gerd Schmitz +16 more
TL;DR: Evidence is presented that TD is caused by mutations in ABC1, encoding a member of the ATP-binding cassette (ABC) transporter family, located on chromosome 9q22–31, which has implications for the understanding of cellular HDL metabolism and reverse cholesterol transport, and its association with premature cardiovascular disease.
Journal ArticleDOI
ABCG1 (ABC8), the human homolog of the Drosophila white gene, is a regulator of macrophage cholesterol and phospholipid transport
Jochen Klucken,Christa Büchler,Evelyn Orsó,Wolfgang E. Kaminski,Mustafa Porsch-Özcürümez,Gerhard Liebisch,Michael Kapinsky,Wendy Diederich,Wolfgang Drobnik,Michael Dean,Rando Allikmets,Gerd Schmitz +11 more
TL;DR: It is reported here that the ATP-binding cassette (ABC) transporter ABCG1 (ABC8) is induced in monocyte-derived macrophages during cholesterol influx mediated by acetylated low-density lipoprotein, defining a biologic activity for ABC transporters in Macrophages.
Journal ArticleDOI
The Zinc Finger Protein 202 (ZNF202) Is a Transcriptional Repressor of ATP Binding Cassette Transporter A1 (ABCA1) and ABCG1 Gene Expression and a Modulator of Cellular Lipid Efflux
Mustafa Porsch-Özcürümez,Thomas Langmann,Susanne Heimerl,Hana Borsukova,Wolfgang E. Kaminski,Wolfgang Drobnik,Christian Honer,Chistoph Schumacher,Gerd Schmitz +8 more
TL;DR: It is demonstrated here that the full-length ZNF202m1 isoform binds to GnT repeats within the promotors of ABCA1 (−229/−210) and ABCG1 (−572/−552) to provide evidence for a functional linkage between ZNF 202 and hypoalphalipoproteinemia.
Journal ArticleDOI
Complete coding sequence, promoter region, and genomic structure of the human ABCA2 gene and evidence for sterol-dependent regulation in macrophages
Wolfgang E. Kaminski,Armin Piehler,Kerstin Püllmann,Mustafa Porsch-Özcürümez,Chinh Quoc Duong,Guido Maa Bared,Christa Büchler,Gerd Schmitz +7 more
TL;DR: The complete cDNA and the genomic organization of ABCA2, another member of the human ABC A transporter A subfamily, are reported and a potential role forABCA2 in macrophage lipid metabolism and neural development is suggested.
Journal ArticleDOI
ATP-binding cassette transporter A1 (ABCA1) in macrophages: a dual function in inflammation and lipid metabolism?
Gerd Schmitz,Wolfgang E. Kaminski,Mustafa Porsch-Özcürümez,Jochen Klucken,Evelyn Orsó,Marek Bodzioch,Christa Büchler,Wolfgang Drobnik +7 more
TL;DR: It is demonstrated here that the ATP-binding cassette (ABC) transporter ABCA1 is induced during differentiation of human monocytes into macrophages, indicating a dual regulatory function for ABCA 1 in macrophage lipid metabolism and inflammation.