M
Mutsuko Hara
Researcher at Juntendo University
Publications - 52
Citations - 1947
Mutsuko Hara is an academic researcher from Juntendo University. The author has contributed to research in topics: Transcription factor & Chromatin immunoprecipitation. The author has an hindex of 21, co-authored 51 publications receiving 1672 citations.
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Journal ArticleDOI
Antimicrobial Peptides Human β-Defensins and Cathelicidin LL-37 Induce the Secretion of a Pruritogenic Cytokine IL-31 by Human Mast Cells
François Niyonsaba,Hiroko Ushio,Mutsuko Hara,Hidenori Yokoi,Mitsutoshi Tominaga,Kenji Takamori,Naoki Kajiwara,Hirohisa Saito,Isao Nagaoka,Hideoki Ogawa,Ko Okumura +10 more
TL;DR: The ability of hBDs and LL-37 to stimulate the production and release of IL-31 by human mast cells provides a novel mechanism by which skin-derived antimicrobial peptides/proteins may contribute to inflammatory reactions and suggests a central role of these peptides in the pathogenesis of skin disorders.
Journal ArticleDOI
Antimicrobial peptides human β‐defensin (hBD)‐3 and hBD‐4 activate mast cells and increase skin vascular permeability
Xuejun Chen,François Niyonsaba,Hiroko Ushio,Mutsuko Hara,Hidenori Yokoi,Kenji Matsumoto,Hirohisa Saito,Isao Nagaoka,Shigaku Ikeda,Ko Okumura,Hideoki Ogawa +10 more
TL;DR: The key role of hBD is suggested in inflammatory responses by recruiting and activating mast cells, and increasing vascular permeability.
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IL-33–Mediated Innate Response and Adaptive Immune Cells Contribute to Maximum Responses of Protease Allergen–Induced Allergic Airway Inflammation
Seiji Kamijo,Haruna Takeda,Haruna Takeda,Tomoko Tokura,Mayu Suzuki,Mayu Suzuki,Kyoko Inui,Kyoko Inui,Mutsuko Hara,Hironori Matsuda,Akira Matsuda,Keisuke Oboki,Tatsukuni Ohno,Hirohisa Saito,Susumu Nakae,Katsuko Sudo,Hajime Suto,Saori Ichikawa,Saori Ichikawa,Hideoki Ogawa,Ko Okumura,Toshiro Takai +21 more
TL;DR: The results suggest cooperation of adaptive immune cells and IL-33–responsive innate cells in protease-dependent allergic airway inflammation.
Journal ArticleDOI
The extra domain A of fibronectin stimulates murine mast cells via Toll-like receptor 4
Srie Prihianti Gondokaryono,Hiroko Ushio,François Niyonsaba,Mutsuko Hara,Hiroshi Takenaka,Sumanasiri T.M. Jayawardana,Shigaku Ikeda,Ko Okumura,Hideoki Ogawa +8 more
TL;DR: Results suggest that the TLR4‐mediated activation of mast cells by endogenous ligand FN‐EDA might contribute to the pathogenesis of RA through proinflammatory cytokine production.
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Cytokine milieu modulates release of thymic stromal lymphopoietin from human keratinocytes stimulated with double-stranded RNA.
Hirokazu Kinoshita,Toshiro Takai,Tuan Anh Le,Seiji Kamijo,Xiao-Ling Wang,Hiroko Ushio,Mutsuko Hara,Junko Kawasaki,Anh Tuan Vu,Takasuke Ogawa,Hendra Gunawan,Shigaku Ikeda,Ko Okumura,Hideoki Ogawa +13 more
TL;DR: The results imply that a vicious cycle exists between AD with T(H)2-type inflammation and viral infections and a possible blockade of this cycle by other cytokine milieus provided by cells, such as T(h)1, regulatory T, and T( H)17 cells.