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Shigaku Ikeda
Researcher at Juntendo University
Publications - 296
Citations - 7271
Shigaku Ikeda is an academic researcher from Juntendo University. The author has contributed to research in topics: Keratinocyte & Medicine. The author has an hindex of 42, co-authored 270 publications receiving 6320 citations.
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Journal ArticleDOI
Mutations in ATP2C1, encoding a calcium pump, cause Hailey-Hailey disease
Zhilan Hu,Jeannette M. Bonifas,Jenna Beech,Graham Bench,Takako Shigihara,Hideoki Ogawa,Shigaku Ikeda,Theodora M. Mauro,Ervin H. Epstein +8 more
TL;DR: The identification of mutations in ATP2C1, encoding the human homologue of an ATP-powered pump that sequesters calcium into the Golgi in yeast, is reported in 21 HHD kindreds, providing an understanding of the molecular basis of HHD and underscore the importance of calcium control to the functioning of stratified squamous epithelia.
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Genome-wide association study identifies eight new susceptibility loci for atopic dermatitis in the Japanese population
Tomomitsu Hirota,Atsushi Takahashi,Michiaki Kubo,Tatsuhiko Tsunoda,Kaori Tomita,Masafumi Sakashita,Takechiyo Yamada,Shigeharu Fujieda,Shota Tanaka,Satoru Doi,Akihiko Miyatake,Tadao Enomoto,Chiharu Nishiyama,Nobuhiro Nakano,Keiko Maeda,Ko Okumura,Hideoki Ogawa,Shigaku Ikeda,Emiko Noguchi,Tohru Sakamoto,Nobuyuki Hizawa,Koji Ebe,Hidehisa Saeki,Takashi Sasaki,Tamotsu Ebihara,Masayuki Amagai,Satoshi Takeuchi,Masutaka Furue,Yusuke Nakamura,Mayumi Tamari +29 more
TL;DR: The findings advance the understanding of the genetic basis of atopic dermatitis and replicate the associations of the FLG, C11orf30, TMEM232-SLC25A46, TNFRSF6B-ZGPAT, OVOL1, ACTL9 and KIF3A-IL13 loci that were previously reported in GWAS of European and Chinese individuals.
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A randomized double-blind trial of intravenous immunoglobulin for pemphigus
Masayuki Amagai,Shigaku Ikeda,Hiroshi Shimizu,Hajime Iizuka,Katsumi Hanada,Setsuya Aiba,Fumio Kaneko,Seiichi Izaki,Kunihiko Tamaki,Zenro Ikezawa,Masahiro Takigawa,Mariko Seishima,Toshihiro Tanaka,Yoshiki Miyachi,Ichiro Katayama,Yuji Horiguchi,Sachiko Miyagawa,Fukumi Furukawa,Keiji Iwatsuki,Michihiro Hide,Yoshiki Tokura,Masutaka Furue,Takashi Hashimoto,Hironobu Ihn,Sakuhei Fujiwara,Takeji Nishikawa,Hideoki Ogawa,Yasuo Kitajima,Koji Hashimoto +28 more
TL;DR: Intravenous immunoglobulin (400 mg/kg/d for 5 d) in a single cycle is an effective and safe treatment for patients with pemphigus who are relatively resistant to systemic steroids.
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Synergistic effect of antibacterial agents human β-defensins, cathelicidin LL-37 and lysozyme against Staphylococcus aureus and Escherichia coli
Xuejun Chen,François Niyonsaba,Hiroko Ushio,Daiju Okuda,Isao Nagaoka,Shigaku Ikeda,Ko Okumura,Hideoki Ogawa +7 more
TL;DR: Results provide a novel evidence of antimicrobial mechanism of natural human skin-derived antibacterial agents against bacterial infection, and their involvement in innate immunity.
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Antimicrobial peptides human β‐defensin (hBD)‐3 and hBD‐4 activate mast cells and increase skin vascular permeability
Xuejun Chen,François Niyonsaba,Hiroko Ushio,Mutsuko Hara,Hidenori Yokoi,Kenji Matsumoto,Hirohisa Saito,Isao Nagaoka,Shigaku Ikeda,Ko Okumura,Hideoki Ogawa +10 more
TL;DR: The key role of hBD is suggested in inflammatory responses by recruiting and activating mast cells, and increasing vascular permeability.