N
N Jacques
Researcher at Institut Gustave Roussy
Publications - 5
Citations - 626
N Jacques is an academic researcher from Institut Gustave Roussy. The author has contributed to research in topics: Lung cancer & Carcinoma. The author has an hindex of 5, co-authored 5 publications receiving 563 citations.
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Journal ArticleDOI
A direct comparison of CellSearch and ISET for circulating tumour-cell detection in patients with metastatic carcinomas.
Françoise Farace,Françoise Farace,Christophe Massard,Nadege Vimond,Françoise Drusch,N Jacques,Fanny Billiot,Agnès Laplanche,Anne Chauchereau,Ludovic Lacroix,Ludovic Lacroix,David Planchard,S. Le Moulec,Fabrice Andre,Fabrice Andre,Karim Fizazi,Karim Fizazi,J-C. Soria,J-C. Soria,Philippe Vielh +19 more
TL;DR: Comparisons of two CTC detection systems based on the expression of the EpCAM antigen or on cell size highlight important discrepancies between the numbers of CTC enumerated by both techniques, especially in patients with metastatic lung carcinoma.
Journal ArticleDOI
Efficacy, Safety, and Biomarkers of Single-Agent Bevacizumab Therapy in Patients with Advanced Hepatocellular Carcinoma
Valérie Boige,David Malka,Abderrahmane Bourredjem,Clarisse Dromain,Charlotte Baey,N Jacques,Jean-Pierre Pignon,Nadege Vimond,Nathalie Bouvet-Forteau,Thierry de Baere,Michel Ducreux,Françoise Farace +11 more
TL;DR: Bvacizumab is active and well tolerated in patients with advanced HCC and the clinical value of CECs, IL-6, and IL-8 warrants further investigation.
Journal ArticleDOI
Levels of circulating CD45 dim CD34 + VEGFR2 + progenitor cells correlate with outcome in metastatic renal cell carcinoma patients treated with tyrosine kinase inhibitors
Françoise Farace,Marine Gross-Goupil,Elodie Tournay,Melissa Taylor,Melissa Taylor,Nadege Vimond,N Jacques,Fanny Billiot,Audrey Mauguen,Catherine Hill,Bernard Escudier +10 more
TL;DR: Monitoring CD45dimCD34+VEGFR2+ progenitor cells, plasma VEGF and SDF-1α levels could be of clinical interest in TKI-treated mRCC pts to predict outcome.
Journal ArticleDOI
Quantification of circulating mature endothelial cells using a whole blood four-color flow cytometric assay.
N Jacques,Nadege Vimond,Rosa Conforti,Franck Griscelli,Yann Lécluse,Agnès Laplanche,David Malka,Philippe Vielh,Françoise Farace +8 more
TL;DR: The assay proposed here allows reproducible and sensitive measurement of CEC by flow cytometry and could help evaluate CEC as biomarkers of anti-angiogenic therapies in large cohorts of patients.
Journal ArticleDOI
Clinical value of circulating endothelial cell levels in metastatic colorectal cancer patients treated with first-line chemotherapy and bevacizumab
David Malka,Valérie Boige,Valérie Boige,N Jacques,Nadege Vimond,Antoine Adenis,Eveline Boucher,J-Y Pierga,Thierry Conroy,Bruno Chauffert,E. Francois,P. Guichard,Marie-Pierre Galais,F. Cvitkovic,Michel Ducreux,Françoise Farace,Françoise Farace +16 more
TL;DR: CEC levels at baseline and after one treatment cycle may independently predict ORR and PFS in mCRC patients starting first-line bevacizumab and chemotherapy.