N. Nasuelli

TL;DR: This study confirms that M SC transplantation into the spinal cord of ALS patients is safe and that MSCs might have a clinical use for future ALS cell based clinical trials.

TL;DR: The results seem to demonstrate that MSCs represent a good chance for stem cell cell-based therapy in ALS and that intraspinal injection of M SCs is safe also in the long term.

TL;DR: A safe cell therapy approach that will allow for the treatment of larger pools of patients for later-phase ALS clinical trials, while warranting good reproducibility is described.

TL;DR: There is a good chance that expanded mesenchymal stem cells isolated from sporadic ALS patients might be used as a cell-based therapy for ALS patients, and extensive in vitro expansion of patient MSCs does not involve any functional modification of the cells, including chromosomal alterations or cellular senescence.

TL;DR: A temporal correlation between administration of ChAdOx1 nCoV-19 (ABW1277) vaccine and GBS without evidence of other predisposing infectious or autoimmune factors is described.