Extrachromosomal rDNA circles--a cause of aging in yeast.

Ceramide in apoptosis: an overview and current perspectives.

Evolutionary theory predicts substantial interspecific and intraspecific differences in the proximal mechanisms of ageing. Our goal here is to seek evidence for common (‘public’) mechanisms among diverse organisms amenable to genetic analysis. Oxidative damage is a candidate for such a public mechanism of ageing. Long-lived strains are relatively resistant to different environmental stresses. The extent to which these stresses produce oxidative damage remains to be established.

Genetic analysis of ageing: Role of oxidative damage and environmental stresses

Toward a unified theory of caloric restriction and longevity regulation.

In mammals, ceramide, a key intermediate in sphingolipid metabolism and an important signaling molecule, is synthesized by a family of six ceramide synthases (CerS), each of which synthesizes ceramides with distinct acyl chain lengths. There are a number of common biochemical features between the CerS, such as their catalytic mechanism, and their structure and intracellular localization. Different CerS also display remarkable differences in their biological properties, with each of them playing distinct roles in processes as diverse as cancer and tumor suppression, in the response to chemotherapeutic drugs, in apoptosis, and in neurodegenerative diseases.

https://iubmb.onlinelibrary.wiley.com/doi/pdf/10.1002/iub.319

N. P. D'mello

Papers

Cloning and characterization of LAG1, a longevity-assurance gene in yeast.