N
N T Thuong
Researcher at French Institute of Health and Medical Research
Publications - 18
Citations - 1669
N T Thuong is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Oligonucleotide & Triple helix. The author has an hindex of 14, co-authored 16 publications receiving 1661 citations. Previous affiliations of N T Thuong include Centre national de la recherche scientifique.
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Short modified antisense oligonucleotides directed against Ha-ras point mutation induce selective cleavage of the mRNA and inhibit T24 cells proliferation.
TL;DR: This study shows that it is possible to design antisense agents that will inactivate the mutated oncogene but not the protooncogene which is generally essential to cell survival.
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Sequence-specific photo-induced cross-linking of the two strands of double-helical DNA by a psoralen covalently linked to a triple helix-forming oligonucleotide.
TL;DR: Such psoralen-oligonucleotide conjugates are probes of sequence-specific triple-helix formation and could be used to selectively control gene expression or to induce site-directed mutations.
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Sequence-specific binding and photocrosslinking of alpha and beta oligodeoxynucleotides to the major groove of DNA via triple-helix formation.
TL;DR: Results show that it is possible to recognize an oligopurine in a DNA double helix via local triple-helix formation and to target photochemical reactions to specific sequences in both double-stranded and single-stranding nucleic acids.
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Sequence-specific recognition and cleavage of duplex DNA via triple-helix formation by oligonucleotides covalently linked to a phenanthroline-copper chelate.
Jean-Christophe François,Tula Saison-Behmoaras,C Barbier,M Chassignol,N T Thuong,Claude Hélène +5 more
TL;DR: It is proposed that the phenanthroline ring carried by the oligonucleotide intercalates from the major groove and that copper chelation locks the complex in place from within the minor groove where the cleavage reaction occurs.
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Triple-helix formation by oligonucleotides containing the three bases thymine, cytosine, and guanine.
TL;DR: The present results provide a rational basis for the development of triplex-forming oligonucleotides targeted to specific sequences of the HIV provirus integrated in its host genome.