In vitro cytotoxicity and antimicrobial evaluation of novel 24–28 membered Schiff base octaazamacrocyclic complexes of manganese(II): Synthesis, characterization, DFT and molecular docking studies

Spectroscopic studies of Transition metal complexes

Novel unsymmetrical Schiff bases comprising azomethine spin-off having ferrocene moiety at one\nend and simple aromatic component attached imine at other end, capable of sensing multiple metal\nions have been synthesized. The MLCT charge transfer band in UV-Visible studies upon coordination\nwith metal ions with receptors is recorded particularly for Cu2+ ions. The observed ΔEp values with\nchange in scan rate for metal free and metal added receptor solution suggest quasi-reversible process.\nAgar well diffusion method and molecular docking studies reveals that the synthesized compounds\ninhibit more efficiently fungi rather than bacteria, which hampers the progress of microbial research,\nas the available antifungal agents are minimal compared to antibacterial counterpart.

Spectral and Electrochemical Sensing Studies of UnsymmetricalSchiff Bases having Enhanced Antifungal Activity

Abstract A series of macrocyclic Cu2+, Ni2+, and Co2+ complexes was synthesized using a template reaction between triethylenetetramine and dibenzoylmethane. These complexes may be represented by the general formula [M(C21H26N4)X2], where M = Cu2+, Ni2+, and Co2+ and X = NO3ˉ, Clˉ, and CH3COOˉ. Various techniques, including elemental analysis, molar conductance, magnetic moment, PXRD, thermal investigations, EPR, IR, UV-visible, and mass spectral studies, were used to characterize the synthesized complexes. Their results suggested the distorted octahedral geometry for copper complexes and octahedral geometry for nickel and cobalt complexes. All complexes showed molar conductance in the range of 8–20 ohm−1 cm2 mol−1 that indicated the non-electrolytic nature. The DFT studies of all complexes were also performed to analyze the stability of complexes. Antibacterial activities of all complexes were also examined, and it was observed that complexes [Ni(C21H26N4)(Cl)2] and [Co(C21H26N4)(Cl)2] exhibited remarkable antibacterial activity. Moreover, complex [Co(C21H26N4)(NO3)2] showed miraculous antioxidant activity, even better than that of ascorbic acid and other complexes. The docking studies of [Ni(C21H26N4)(Cl)2] and [Co(C21H26N4)(Cl)2] were also performed to enforce the results obtained from the antibacterial study of these complexes. Furthermore, the drug-likeness property of all complexes was also evaluated with the help of ADMET studies. Graphical abstract

Synthesis, spectral, biological, and computational studies of template engineered macrocyclic metal complexes

Design, and synthesis of a plasticizer- Schiff’s bases complexes as additive for polystyrene

Facile one pot synthesis of a series of seven tetraamide macrocyclic complexes of first row transition metal ions such as Cr(III), Mn(II), Fe(III), Co(II), Ni(II), Cu(II) and Zn(II) is carried out ...

N. Tazin

Papers

Facile one pot synthesis of tetraamide macrocyclic complexes using malonyldihydrazide and p-nitrobenzaldehyde at room temperature