Nadine Spielmann

TL;DR: The avenue of saliva diagnostics incorporating transcriptomic, proteomic and metabolomic findings will enable us to connect salivary molecular analytes to monitor therapies, therapeutic outcomes, and finally disease progression in cancer.

TL;DR: This study supports that tumor-derived exosomes provide a mechanism in the development of discriminatory biomarkers in saliva and distal systemic diseases.

TL;DR: It is shown that previously discovered and validated salivary OSCC biomarkers are discriminatory and reproducible in a different ethnic cohort and support the feasibility to implement multi-center, multi-ethnicity clinical trials towards the pivotal validation ofSalivary biomarkers for OSCC detection.

TL;DR: The high degree of sequence alignment to annotated exons and introns for each of the respective reference genomes, with sequence coverage spanning the full length of the genes, provides strong evidence that the salivary transcriptome is a complex RNA network.

TL;DR: The evolution of salivary diagnostics has reached a new level toward the goal of using saliva as a powerful fluid for early detection and the first line of diagnosis for life-threatening diseases such as cancer, metabolic disorders, infections, and inflammatory diseases.