Christopher A. Schafer

TL;DR: Saliva and its significance as a source of indicators for local, systemic, and infectious disorders is discussed and contemporary innovations and recent discoveries that deem saliva a mediator of the body's physiological condition are explored.

TL;DR: This study supports that tumor-derived exosomes provide a mechanism in the development of discriminatory biomarkers in saliva and distal systemic diseases.

TL;DR: The hypothesis that tumor-shed secretory lipidic vesicles called exosome-like microvesicles called ELMs that serve as protective carriers of tissue-specific information, mRNAs, and proteins, throughout the vasculature and bodily fluids are evaluated to strengthen the link between distal tumor progression and the biomarker discovery of saliva through the ELMs.

TL;DR: This paper overviews salivary diagnostics from biomarker development to the multitude of techniques utilized in identifying saliva-based molecular indicators of disease and presents oral fluids as an easily accessible noninvasive alternative to traditional diagnostic avenues and not just an essential component of the digestive process.

TL;DR: The potential of serum, saliva, and synovial fluids as reservoirs of biochemical information capable of discerning specific disorders, including those correlated with orofacial pain are overviewed.