Nahid F. Mivechi

TL;DR: It is demonstrated that newly synthesized pre-mRNAs colocalize to the HSF-1 punctate granules after heat shock, suggesting that these granules are sites of transcription, and evidence that glycogen synthase kinase 3β (GSK-3β) and extracellular signal-regulated kinase mitogen-activated protein kinase (ERK MAPK) participate in the down regulation of HSF -1 transcriptional activity.

TL;DR: It is demonstrated that Hsf1 is critical for maintaining cellular integrity after heat stress and that cells from hsf1−/− mice lack the ability to develop thermotolerance.

TL;DR: It is reported here that hsf2−/− mice exhibit multiple phenotypes, including an increased prenatal lethality occurring between mid‐gestation to birth, with fetal death probably due to central nervous system defects including collapse of the lateral ventricles and ventricular hemorrhages, and suggest that hSF2 has a major function in controlling expression of genes important for embryonic development and maintenance of sperm production.

TL;DR: The data presented here link the loss of Hsf1-dependent function to decreased susceptibility to spontaneous lymphomagenesis, which may have implications for cancer prevention and therapy.

TL;DR: It is reported here that the expression of hsp70.1 andhsp 70.3 is developmentally regulated at the transcriptional level, and an overlapping expression pattern for both genes is observed during embryo development and in the tissues of adult mice.