N
Namrata Gupta
Publications - 2
Citations - 583
Namrata Gupta is an academic researcher. The author has contributed to research in topics: Migraine with aura & Aura. The author has an hindex of 2, co-authored 2 publications receiving 551 citations.
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A dominant-negative mutation in the TRESK potassium channel is linked to familial migraine with aura.
Ronald G. Lafrenière,M. Zameel Cader,M. Zameel Cader,Jean-François Poulin,Isabelle Andres-Enguix,Maryse Simoneau,Namrata Gupta,Karine Boisvert,François Lafrenière,Shannon McLaughlan,Marie-Pierre Dubé,Martin M Marcinkiewicz,Sreeram V. Ramagopalan,Olaf Ansorge,Bernard Brais,Jorge Sequeiros,José Pereira-Monteiro,Lyn R. Griffiths,Stephen J. Tucker,George C. Ebers,Guy A. Rouleau +20 more
TL;DR: A frameshift mutation, F139WfsX24, is reported, which segregates perfectly with typical migraine with aura in a large pedigree and demonstrates that it causes a complete loss of TRESK function and that the mutant subunit suppresses wild-type channel function through a dominant-negative effect, thus explaining the dominant penetrance of this allele.
A dominant-negative mutation in the TRESK potassium channel is linked to familial migraine with aura
Ronald G. Lafrenière,M. Zameel Cader,M. Zameel Cader,Jean-François Poulin,Isabelle Andres-Enguix,Maryse Simoneau,Namrata Gupta,Karine Boisvert,François Lafrenière,Shannon McLaughlan,Marie-Pierre Dubé,Martin M Marcinkiewicz,Sreeram V. Ramagopalan,Olaf Ansorge,Bernard Brais,Jorge Sequeiros,José Pereira-Monteiro,Lyn R. Griffiths,Stephen J. Tucker,George C. Ebers,Guy A. Rouleau +20 more
TL;DR: In this article, a frameshift mutation, F139WfsX24, was found to cause complete loss of TRESK function and that the mutant subunit suppresses wild-type channel function through a dominant negative effect, thus explaining the dominant penetrance of this allele.