Showing papers by "Natalia V. Gulyaeva published in 2000"
TL;DR: The present data indicate that in a model of delayed apoptotic neurodegeneration as induced by ethylcholine aziridinium neuronal cell death in vitro and in vivo is independent of the cytotoxic potential of nitric oxide.
27 citations
TL;DR: The free radical nitric oxide (NO) is a neuronal messenger which is synthesized from L-arginine and O2 by Nitric oxide synthase (NOS), and in the synthesis NO and L-citrulline are produced in a stoichiometric 1[ratio ]1 relation.
Abstract: The free radical nitric oxide (NO) is a neuronal messenger which is synthesized from L-arginine and O2 by nitric oxide synthase (NOS). In the synthesis NO and L-citrulline are produced in a stoichiometric 1[ratio ]1 relation. The activity of NOS was analysed in homogenates of the rat tapeworm Hymenolepis diminuta by measuring the formation of L-[3H]citrulline after incubation with L-[3H]arginine. The nature of NOS in H. diminuta was determined by studying the effect of 3 types of NOS inhibitors: (1) L-NAME, (2) EGTA, (3) 7-nitro-indazole. All inhibitors caused a significant but not complete reduction in the formation of L-[3H]citrulline. The results are discussed against the background of nerve cells and fibres positive for NADPH-diaphorase staining in H. diminuta.
18 citations
TL;DR: The authors' results indicate a link between early adverse socio-emotional experience and the maturation of NADPH-reactive neurons in prefrontal cortical areas and in subdivisions of the nucleus accumbens and in the corpus callosum in precocious rodent Octodon degus.
17 citations