Natanael Zarco

TL;DR: NAR prevents CCl4 induced liver inflammation, necrosis and fibrosis, due to its antioxidant capacity as a free radical inhibitor and by inhibiting the NF-κB, TGF-β- Smad3 and JNK-Smad3 pathways.

TL;DR: The results show that caffeine prevents experimental cirrhosis; the mechanisms of action are associated with its antioxidant properties and mainly by its ability to block the elevation of the profibrogenic cytokine transforming growth factor-&bgr;, which may be associated with attenuation of the inflammatory and fibrotic processes.

TL;DR: It is determined that the presence of GAS1 also triggers the dephosphorylation of BAD, which, in turn, provokes the release of Cytochrome-c from the mitochondria to the cytosol activating caspase-9, prompting the activity of caspases-3 and resulting in apoptosis of the cells.

TL;DR: L-theanine prevents CCl4-induced experimental hepatic cirrhosis in rats by blocking the main pro-inflammatory and pro-fibrogenic signals.

TL;DR: This study demonstrates that hesperidin prevents experimental necrosis and fibrosis and supports earlier findings demonstrating the beneficial effect of hes peridin against liver damage.