Nattayaporn Apaijai

TL;DR: It is found that in the HFD group, metformin significantly attenuated the insulin resistant condition by improving metabolic parameters, decreasing peripheral and brain oxidative stress levels, and improving learning behavior, compared to the vehicle-treated group.

TL;DR: It is demonstrated that both drugs significantly improved the metabolic parameters and decreased circulating and brain oxidative stress levels in HFD-induced insulin-resistant rats and completely prevented brain and hippocampal mitochondrial dysfunction and equally improved the learning behaviors impaired by the HFD.

TL;DR: Dipeptidyl peptidase‐4 (DPP‐4) inhibitors, vildagliptin and sitagli leptin, are oral anti‐diabetic drugs often prescribed in patients with cardiovascular disease and their effects were sought in a murine model of insulin resistance.

TL;DR: It is demonstrated that curcuminoids significantly decreased MI associated with CABG, which may account for their cardioprotective effects shown in this study.

TL;DR: It is concluded that vildagliptin is more effective in preventing cardiac sympathovagal imbalance and cardiac dysfunction, as well as cardiac mitochondrial dysfunction, than metformin in rats with insulin resistance induced by high-fat diet.