N
Neil A. Clipstone
Researcher at Northwestern University
Publications - 21
Citations - 6073
Neil A. Clipstone is an academic researcher from Northwestern University. The author has contributed to research in topics: Calcineurin & Signal transduction. The author has an hindex of 20, co-authored 21 publications receiving 5924 citations. Previous affiliations of Neil A. Clipstone include Loyola University Chicago & Stanford University.
Papers
More filters
Journal ArticleDOI
Identification of calcineurin as a key signalling enzyme in T-lymphocyte activation
TL;DR: It is reported here that overexpression of calcineurin in Jurkat cells renders them more resistant to the effects of CsA and FK506 and augments both NFAT- and NFIL2A-dependent transcription.
Journal ArticleDOI
The mechanism of action of cyclosporin A and FK506.
Steffan N. Ho,Neil A. Clipstone,Luika Timmermann,Jeffrey P. Northrop,Isabella A. Graef,David Fiorentino,Jamie Nourse,Gerald R. Crabtree +7 more
TL;DR: The immunosuppressants cyclosporin A (CsA), FK506, and rapamycin suppress the immune response by inhibiting evolutionary conserved signal transduction pathways by creating composite surfaces that block the activity of specific targets.
Journal ArticleDOI
Signal transmission between the plasma membrane and nucleus of t lymphocytes
TL;DR: The role of NF-Kl3 and AP-l in T Cell Activation and the role of Calcineurin in Other Cells and Species are discussed.
Journal ArticleDOI
Rapid shuttling of NF-AT in discrimination of Ca2+ signals and immunosuppression.
Luika A. Timmerman,Neil A. Clipstone,Neil A. Clipstone,Steffan N. Ho,Jeffrey P. Northrop,Gerald R. Crabtree +5 more
TL;DR: It is reported that sustained high concentrations of Ca2+, but not transient pulses, are required to maintain NF-AT transcription factors in the nucleus, where they participate in Ca2+-dependent induction of genes required for lymphocyte activation and proliferation.
Journal ArticleDOI
Nuclear localization of NF-ATc by a calcineurin-dependent, cyclosporin-sensitive intramolecular interaction.
TL;DR: It is shown that translocation requires two redundant nuclear localization sequences and that one sequence is in an intramolecular association with phosphorserines in a conserved motif located at the amino terminus of each NF-AT protein.