J
Jeffrey P. Northrop
Researcher at Stanford University
Publications - 22
Citations - 9927
Jeffrey P. Northrop is an academic researcher from Stanford University. The author has contributed to research in topics: Transcription factor & Enhancer. The author has an hindex of 17, co-authored 22 publications receiving 9698 citations.
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Journal ArticleDOI
Lipofection: a highly efficient, lipid-mediated DNA-transfection procedure
Philip L. Felgner,Thomas R. Gadek,Marilyn Holm,Richard Bolton Roman,Hardy W. Chan,Michael Wenz,Jeffrey P. Northrop,Gordon M. Ringold,Mark Danielsen +8 more
TL;DR: Depending upon the cell line, lipofection is from 5- to greater than 100-fold more effective than either the calcium phosphate or the DEAE-dextran transfection technique.
Journal ArticleDOI
The mechanism of action of cyclosporin A and FK506.
Steffan N. Ho,Neil A. Clipstone,Luika Timmermann,Jeffrey P. Northrop,Isabella A. Graef,David Fiorentino,Jamie Nourse,Gerald R. Crabtree +7 more
TL;DR: The immunosuppressants cyclosporin A (CsA), FK506, and rapamycin suppress the immune response by inhibiting evolutionary conserved signal transduction pathways by creating composite surfaces that block the activity of specific targets.
Journal ArticleDOI
NF-AT components define a family of transcription factors targeted in T-cell activation
Jeffrey P. Northrop,Steffan N. Ho,Lei Chen,Daryl J. Thomas,Luika A. Timmerman,Garry P. Nolan,Arie Admon,Gerald R. Crabtree +7 more
TL;DR: This work purify two proteins encoded by separate genes that represent the pre-existing and cytosolic components of NF-AT, indicating that distinct signalling pathways converge onNF-ATc to regulate its function.
Journal ArticleDOI
Rapid shuttling of NF-AT in discrimination of Ca2+ signals and immunosuppression.
Luika A. Timmerman,Neil A. Clipstone,Neil A. Clipstone,Steffan N. Ho,Jeffrey P. Northrop,Gerald R. Crabtree +5 more
TL;DR: It is reported that sustained high concentrations of Ca2+, but not transient pulses, are required to maintain NF-AT transcription factors in the nucleus, where they participate in Ca2+-dependent induction of genes required for lymphocyte activation and proliferation.
Journal ArticleDOI
Transmission of signals from the T lymphocyte antigen receptor to the genes responsible for cell proliferation and immune function: the missing link.
TL;DR: Article de synthese sur la lyse des cellules cibles par les lymphocytes T. cytoplasmiques sur la perforine et son mode d'action.