Journal ArticleDOI
Signal transmission between the plasma membrane and nucleus of t lymphocytes
Reads0
Chats0
TLDR
The role of NF-Kl3 and AP-l in T Cell Activation and the role of Calcineurin in Other Cells and Species are discussed.Abstract:
INITIATING THE GENETIC PROGRAM LEADING TO T CELL ACTIVATION 1057 Integration of the Diverse Signals Required for T Cell Activation on the Regulatory Regions of Early Genes ..... .. . .. . .. . . ... . 1057 The NF-AT Transcriptional Complex . . . . . . . . . . . . . . . . . . . . . . . . . . .. 1058 An Association Between JUIl D and Octl Appears to Play an Important Role ill Activating the IL-2 Gene ....... . .... .... ..... . .. . . 1062 The Roles of NF-Kl3 and AP-l in T Cell Activation . . . . . ... . . . .. .. . . . 1063 CALCINEURIN: AN ESSENTIAL SIGNALLING INTERMEDIATE ......... 1064 Calcineurin in Other Cells and Species .. . ...... . .. . 1069 Is Calcineurin a Rate-Limiting Step in T Cell Activation? 1070read more
Citations
More filters
Journal ArticleDOI
TRANSCRIPTION FACTORS OF THE NFAT FAMILY:Regulation and Function
TL;DR: Recent data on the diversity of the NFAT family of transcription factors, the regulation of NFAT proteins within cells, and the cooperation ofNFAT proteins with other transcription factors to regulate the expression of inducible genes are discussed.
Journal ArticleDOI
Parallel human genome analysis: microarray-based expression monitoring of 1000 genes
TL;DR: The identification of known and novel heat shock and phorbol ester-regulated genes in human T cells demonstrates the sensitivity of the assay.
Journal ArticleDOI
Calcium oscillations increase the efficiency and specificity of gene expression
TL;DR: It is reported that oscillations reduce the effective Ca2+ threshold for activating transcription factors, thereby increasing signal detection at low levels of stimulation and providing direct evidence that [Ca2+]i oscillations increase both the efficacy and the information content of Ca2+, leading to gene expression and cell differentiation.
Journal ArticleDOI
Differential activation of transcription factors induced by Ca2+ response amplitude and duration
TL;DR: It is reported here that the amplitude and duration of calcium signals in B lymphocytes controls differential activation of the pro–inflammatory transcriptional regulators NF-κB, c-Jun N-terminal kinase (JNK) and NFAT, revealing a mechanism by which a multifunctional second messenger such as Ca2+ can achieve specificity in signalling to the nucleus.
Journal ArticleDOI
JAKS AND STATS: Biological Implications*
Warren J. Leonard,John J. O'Shea +1 more
TL;DR: The Jak-STAT pathway is the focus of this chapter, a novel mechanism in which cytosolic latent transcription factors, known as signal transducers and activators of transcription (STATs), are tyrosine phosphorylated by Janus family tyrosin kinases (Jaks), allowing STAT protein dimerization and nuclear translocation.
References
More filters
Journal ArticleDOI
Regulatory subunit (CNB1 gene product) of yeast Ca2+/calmodulin-dependent phosphoprotein phosphatases is required for adaptation to pheromone.
Martha S. Cyert,Jeremy Thorner +1 more
TL;DR: In this article, the authors used an assay specific for detection of calcineurin, a Ca2+/calmodulin-dependent phosphoprotein phosphatase, which was purified approximately 5,000fold from extracts of the yeast Saccharomyces cerevisiae.