Rotations and inversions in organic molecules are readily recognizable from the temperature dependence of the NMR spectra. The study of the effects of substituents on the activation barriers of such processes permits the elucidation of reaction mechanisms, and the stability limits of isomers can also be determined. The knowledge of the stability limits is necessary for the specific synthesis of stable rotamers and invertomers.

Detection of Hindered Rotation and Inversion by NMR Spectroscopy

Rotations- und Inversionsprozesse in organischen Molekulen geben sich durch die Temperaturabhangigkeit der NMR-Spektren zu erkennen. Das Studium der Substituenteneffekte auf die Aktivierungsbarrieren solcher Prozesse gestattet die Aufklarung von Reaktionsmechanismen, ferner lassen sich die Stabilitatsgrenzen von Isomeren ermitteln. Die Kenntnis der Stabilitatsgrenzen ist notwendig, um gezielt stabile Rotamere und Invertomere synthetisieren zu konnen.

Nachweis gehinderter Rotationen und Inversionen durch NMR‐Spektroskopie

https://www.rsc.org/suppdata/gc/c3/c3gc36901c/c3gc36901c.pdf

Chitosan: a highly efficient renewable and recoverable bio-polymer catalyst for the expeditious synthesis of α-amino nitriles and imines under mild conditions

Recent advances in asymmetric synthesis using chiral lithium amide bases

Oxidation with metal oxides—II : Oxidation of chalcone phenylhydrazones, pyrazolines, o-aminobenzylidine anils and o-hydroxy benzylidine anils with manganese dioxide

Nicasio P. Marullo

Papers

Stereochemistry of the Decomposition of N-Nitroso- and N-Amino-α,α'-dimethyldibenzylamine1

Restricted rotation about the N-N single bond Linear correlation of rate with substituent

STEREOCHEMISTRY OF THE DECOMPOSITION OF OPTICALLY ACTIVE N-NITROSO AND N-AMINO α,α'-DIMETHYLIDIBENZYLAMINE