N
Nicholas A. Saunders
Researcher at University of Queensland
Publications - 128
Citations - 4665
Nicholas A. Saunders is an academic researcher from University of Queensland. The author has contributed to research in topics: Cellular differentiation & Keratinocyte. The author has an hindex of 37, co-authored 126 publications receiving 4276 citations. Previous affiliations of Nicholas A. Saunders include Translational Research Institute & University of Western Australia.
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Journal ArticleDOI
Role of intratumoural heterogeneity in cancer drug resistance: molecular and clinical perspectives.
Nicholas A. Saunders,Nicholas A. Saunders,Fiona Simpson,Erik W. Thompson,Michelle M. Hill,Liliana Endo-Munoz,Graham R. Leggatt,Rodney F. Minchin,Alexander Guminski,Alexander Guminski +9 more
TL;DR: To deliver curative therapies to patients, modification of current therapeutic strategies to include methods that estimate intratumoural heterogeneity and plasticity will be essential.
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A role for pericytes as microenvironmental regulators of human skin tissue regeneration
Sophie Paquet-Fifield,Holger Schlüter,Amy Li,Amy Li,Tara Aitken,Pradnya Gangatirkar,Daniel Blashki,Rachel Koelmeyer,Normand Pouliot,Manuela Palatsides,Sarah Ellis,Nathalie Brouard,Andrew C.W. Zannettino,Nicholas A. Saunders,Natalie Thompson,Jason Li,Pritinder Kaur +16 more
TL;DR: It is demonstrated that, in organotypic cocultures, dermal pericytes substantially enhanced the intrinsically low tissue-regenerative capacity of human epidermal cells that have committed to differentiate and that this enhancement was independent of angiogenesis.
Journal ArticleDOI
Cornifin, a cross-linked envelope precursor in keratinocytes that is down-regulated by retinoids.
Keith W. Marvin,Margaret D. George,Wataru Fujimoto,Nicholas A. Saunders,Susan H. Bernacki,Anton M. Jetten +5 more
TL;DR: Observations suggest that the protein encoded by SQ37 participates in the assembly of the cross-linked envelope in squamous differentiating cells, and is mediated by transglutaminase type I.
Journal Article
Histone deacetylase inhibitors as potential anti-skin cancer agents.
TL;DR: TSA may have potential as a topical treatment for epidermal malignancies because it induced a reversible growth arrest and transient increases in the acetylation of histone H4 in keratinocytes and squamous carcinoma cells.
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Control of growth regulatory and differentiation-specific genes in human epidermal keratinocytes by interferon gamma. Antagonism by retinoic acid and transforming growth factor beta 1.
TL;DR: Several squamous cell carcinoma cell lines do not show a detectable decrease in cdc2 or increase in transglutaminase type I mRNA levels after IFN-gamma treatment and appear to be altered in their control of squamous differentiation.