N
Nicholas J. Otis
Researcher at United States Department of Agriculture
Publications - 1
Citations - 126
Nicholas J. Otis is an academic researcher from United States Department of Agriculture. The author has contributed to research in topics: Downregulation and upregulation & Kinase. The author has an hindex of 1, co-authored 1 publications receiving 110 citations.
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Prodeath Signaling of G Protein-Coupled Receptor Kinase 2 in Cardiac Myocytes After Ischemic Stress Occurs via Extracellular Signal-Regulated Kinase-Dependent Heat Shock Protein 90-mediated Mitochondrial Targeting
Mai Chen,Priscila Y. Sato,J. Kurt Chuprun,Raymond J. Peroutka,Nicholas J. Otis,Jessica Ibetti,Shi Pan,Shey-Shing Sheu,Erhe Gao,Walter J. Koch +9 more
TL;DR: G protein–coupled receptor kinase 2 is identified as a prodeath kinase in the heart, acting in a novel manner through mitochondrial localization via extracellular signal–regulated kinase regulation.