Shi Pan

TL;DR: G protein–coupled receptor kinase 2 is identified as a prodeath kinase in the heart, acting in a novel manner through mitochondrial localization via extracellular signal–regulated kinase regulation.

TL;DR: Mechanistic studies using human neutrophils demonstrated that inhibition of immune cell chemotaxis is a key mechanism by which TAS2R agonists blocked allergic airway inflammation and exerted anti-asthma effects.

TL;DR: In this paper, the authors explored cellular mechanisms mediating the antimitogenic effect of TAS2R agonists on human airway smooth muscle (ASM) cells and identified a novel class of receptors and pathways that can be targeted to mitigate airway remodeling as well as bronchoconstriction in obstructive airway diseases.

TL;DR: It is plausible that mitochondrial inner membrane has more than just MCU to decode complex intracellular Ca2+ signaling in various cell types, and their potential physiological and pathological implications are discussed.

TL;DR: This paper aims to demonstrate the intracellular integrity of the Ca2+–Ca2+ exchanger system through the use of a simple, straightforward, and scalable “spatially-dense” approach.