N
Nicholas J. Savill
Researcher at University of Edinburgh
Publications - 55
Citations - 2797
Nicholas J. Savill is an academic researcher from University of Edinburgh. The author has contributed to research in topics: Population & Minicircle. The author has an hindex of 28, co-authored 52 publications receiving 2647 citations. Previous affiliations of Nicholas J. Savill include Heriot-Watt University & University of Cambridge.
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Journal ArticleDOI
Optimal reactive vaccination strategies for a foot-and-mouth outbreak in the UK
Michael J. Tildesley,Nicholas J. Savill,Nicholas J. Savill,Darren J. Shaw,Rob Deardon,Stephen P. Brooks,Mark E. J. Woolhouse,Bryan T. Grenfell,Bryan T. Grenfell,Matthew James Keeling +9 more
TL;DR: A model of FMD spread is used to investigate the optimal deployment of reactive ring vaccination of cattle constrained by logistical resources, and the predicted optimal ring size is highly dependent upon logistical constraints but is more robust to epidemiological parameters.
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Modelling Morphogenesis: From Single Cells to Crawling Slugs.
TL;DR: A three-dimensional hybrid cellular automata (CA)/partial differential equation (PDE) model is presented that allows for the study of morphogenesis in simple cellular systems and causes the amoebae to spatially self-organize.
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RNA sequence evolution with secondary structure constraints: comparison of substitution rate models using maximum-likelihood methods.
TL;DR: The most general time-reversible model significantly outperformed any of the simplifications, and the relative merits of all these models for molecular phylogenetics are considered.
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Silent spread of H5N1 in vaccinated poultry.
TL;DR: It is shown that 'silent spread' can occur because of incomplete protection at the flock level, even if a vaccine is effective in individual birds, and the use of unvaccinated sentinels can mitigate, although not completely eliminate, the problem.
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Evolution of RNA editing in trypanosome mitochondria
TL;DR: Two different RNA editing systems have been described in the kinetoplast-mitochondrion of trypanosomatid protists and the possible evolutionary relationship of the C to U and U-insertion editing systems is discussed.