N
Nicolas Demaurex
Researcher at University of Geneva
Publications - 157
Citations - 13538
Nicolas Demaurex is an academic researcher from University of Geneva. The author has contributed to research in topics: Endoplasmic reticulum & Calcium signaling. The author has an hindex of 59, co-authored 146 publications receiving 12605 citations. Previous affiliations of Nicolas Demaurex include University of Calgary & University of Toronto.
Papers
More filters
Journal ArticleDOI
The dendritic cell-specific adhesion receptor DC-SIGN internalizes antigen for presentation to T cells.
Anneke Engering,Teunis B.H. Geijtenbeek,Sandra J. van Vliet,Mietske Wijers,Ellis van Liempt,Nicolas Demaurex,Antonio Lanzavecchia,Jack A.M. Fransen,Carl G. Figdor,Vincent Piguet,Yvette van Kooyk +10 more
TL;DR: It is demonstrated that on DCs DC-SIGN is rapidly internalized upon binding of soluble ligand, which points to a novel function of the adhesion receptor DC- SIGN as an efficient DC-specific Ag receptor that can be used as a target to induce viral and antitumor immunity.
Journal ArticleDOI
A Ca(2+)-activated NADPH oxidase in testis, spleen, and lymph nodes.
Botond Banfi,Gergely Molnár,Andrés D. Maturana,Klaus Steger,Balazs Hegedus,Nicolas Demaurex,Karl-Heinz Krause +6 more
TL;DR: A novel NADPH oxidase that generates superoxide and functions as a H+ channel in a Ca2-dependent manner is identified and is likely to be involved in Ca2+-activated, redox-dependent processes of spermatozoa and lymphocytes such as sperm-oocyte fusion, cell proliferation, and cytokine secretion.
Journal ArticleDOI
Bcl-2 decreases the free Ca2+ concentration within the endoplasmic reticulum
Reyhaneh Foyouzi-Youssefi,Serge Arnaudeau,Christoph Borner,William L. Kelley,Jürg Tschopp,Daniel Pablo Lew,Nicolas Demaurex,Karl-Heinz Krause +7 more
TL;DR: Results suggest that Bcl-2 decreases the free Ca(2+) concentration within the ER lumen by increasing the Ca( 2+) permeability of the ER membrane, which would be compatible with an ion channel function of B cl-2 at the level of theER membrane.
Journal ArticleDOI
mTOR complex 2-Akt signaling at mitochondria-associated endoplasmic reticulum membranes (MAM) regulates mitochondrial physiology
Charles Betz,Daniele Stracka,Cristina Prescianotto-Baschong,Maud Frieden,Nicolas Demaurex,Michael N. Hall +5 more
TL;DR: It is reported that mTORC2 is localized to the endoplasmic reticulum (ER) subcompartment termed mitochondria-associated ER membrane (MAM) and is at the core of a MAM signaling hub that controls growth and metabolism.
Journal ArticleDOI
Calreticulin is essential for integrin-mediated calcium signalling and cell adhesion
Marc G. Coppolino,M Woodside,Nicolas Demaurex,Sergio Grinstein,René St-Arnaud,Shoukat Dedhar +5 more
TL;DR: The results indicate that calreticulin is an essential modulator both of integrin adhesive functions and integrin-initiated signalling, but that it may not play a significant role in the storage of luminal calcium.