N
Nicole Picard
Publications - 5
Citations - 13
Nicole Picard is an academic researcher. The author has contributed to research in topics: Biology & Population. The author has an hindex of 2, co-authored 5 publications receiving 13 citations.
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Schwann cells in the subcutaneous adipose tissue have neurogenic potential and can be used for regenerative therapies
Rhian Stavely,Ryo Hotta,Nicole Picard,Ahmed A. Rahman,Weikang Pan,Sukhada Bhave,Meredith Omer,Wing Lam N. Ho,Richard A. Guyer,Allan M. Goldstein +9 more
TL;DR: SAT-NSC transplant rescued functional deficits in mouse models of gastrointestinal dysmotility, suggesting that SAT could be a valuable source of NSCs with therapeutic potential for treating gastrointestinal motility disorders.
Journal ArticleDOI
Schwann Cells in the Aganglionic Colon of Hirschsprung Disease Can Generate Neurons for Regenerative Therapy
Weikang Pan,Ahmed A. Rahman,Rhian Stavely,Sukhada Bhave,Richard A. Guyer,Meredith Omer,Nicole Picard,Allan M. Goldstein,Ryo Hotta +8 more
TL;DR: In this article , Schwann cells from the aganglionic segment of Hirschsprung disease (HSCR) mice were transplanted into the colon ex vivo and in vivo.
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A distinct transcriptome characterizes neural crest-derived cells at the migratory wavefront during enteric nervous system development.
Rhian Stavely,Ryo Hotta,Richard A. Guyer,Nicole Picard,Ahmed A. Rahman,Meredith Omer,Ádám Soós,Emoke Szocs,Jessica Mueller,Allan M. Goldstein,Nandor Nagy +10 more
TL;DR: In this article , RNA-seq was performed on ENCDCs from the wavefront and the trailing regions, and the results indicated that wavefront-ENCDs exhibited altered expression of ECM and cytoskeletal genes, consistent with a migratory phenotype.
Journal ArticleDOI
Ednrb −/− mice with hirschsprung disease are missing Gad2-expressing enteric neurons in the ganglionated small intestine
TL;DR: It is shown for the first time that ganglionated regions of the Hirschsprung gut lack a neuronal subpopulation, which may explain the persistent gastrointestinal dysfunction after surgical correction of HirschSprung disease.
Posted ContentDOI
Differentiated neuroblastoma cells remain epigenetically poised for de-differentiation to an immature state
Richard A. Guyer,Nicole Picard,Jessica L. Mueller,Andrew J. Murphy,Kristine M. Cornejo,Ryo Hotta,Allan M. Goldstein +6 more
TL;DR: It is demonstrated that neuroblastoma cells can interconvert between a state characterized by expression of neuronal genes and a de-differentiated state, representing potential therapeutic targets for this lethal tumor.